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401474 IKK Inhibitor II, Wedelolactone - CAS 524-12-9 - Calbiochem

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      Overview

      Key Spec Table

      CAS #Empirical Formula
      524-12-9C₁₆H₁₀O₇
      Description
      OverviewThe naturally isolated active ingredient of the herbal medicine, Eclipta alba, that acts as a cell permeable, selective and irreversible inhibitor of IKKα and β kinase activity (IC50 < 10 µM). Inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Has no effects on p38 MAP kinase or Akt.
      Catalogue Number401474
      Brand Family Calbiochem®
      SynonymsWedelolactone, Eclipta alba, 7-Methoxy-5,11,12-trihydroxy-coumestan
      References
      ReferencesKobori, M., et al. 2004. Cell Death Differ. 11, 123.
      Li, C.C., et al. 2003. J. Org. Chem. 68, 8500.
      Mors, W.B., et al. 1989. Toxicon 27, 1003.
      Wagner, H., and Fessler, B. 1986. Planta Med. 5, 374.
      Product Information
      CAS number524-12-9
      ATP CompetitiveN
      FormYellowish-green, crystalline powder
      Hill FormulaC₁₆H₁₀O₇
      Chemical formulaC₁₆H₁₀O₇
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationIKK Inhibitor II, Wedelolactone, CAS 524-12-9, is a cell-permeable, selective, irreversible inhibitor of IKKα and β kinase activity (IC50 = 10 µM).
      Biological Information
      Primary TargetIKKα and β kinase activity
      Primary Target IC<sub>50</sub>< 10 µM against IKKα and β kinase activity
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      401474 0