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401482 IKK-2 Inhibitor V - CAS 978-62-1 - Calbiochem

The IKK-2 Inhibitor V, also referenced under CAS 978-62-1, controls the biological activity of IKK-2. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(3,5-Bis-trifluoromethylphenyl)-5-chloro-2-hydroxybenzamide, IMD-0354

Primary Target: IKK-2
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401482
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
978-62-1C₁₅H₈ClF₆NO₂

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      Description
      OverviewA cell-permeable salicylamide compound that acts as an IKK-2 inhibitor by selectively blocking IκBα phosphorylation (IC50 ~ 250 nM) and thereby prevents the induction of NF-κB p65 nuclear translocation. Shown to offer cardioprotection by reducing IL-1β and MCP-1 production (IC50 < 1 µM) in cardiomyocytes, and ameliorate insulin resistance in KKAy mice by regulating adiponectin release.
      Catalogue Number401482
      Brand Family Calbiochem®
      SynonymsN-(3,5-Bis-trifluoromethylphenyl)-5-chloro-2-hydroxybenzamide, IMD-0354
      References
      ReferencesKamon, J., et al. 2004. Biochem. Biophys. Res. Commun. 323, 242.
      Onai, Y., et al. 2004. Cardiovasc. Res. 63, 51.
      Tanaka, A., et al. 2004. Blood 105, 2324.
      Product Information
      CAS number978-62-1
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₅H₈ClF₆NO₂
      Chemical formulaC₁₅H₈ClF₆NO₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetIKK-2
      Primary Target IC<sub>50</sub>~ 250 nM blocking IκBα phosphorylation
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      401482-5MG 04055977211979

      Documentation

      IKK-2 Inhibitor V - CAS 978-62-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      IKK-2 Inhibitor V - CAS 978-62-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      401482

      References

      Reference overview
      Kamon, J., et al. 2004. Biochem. Biophys. Res. Commun. 323, 242.
      Onai, Y., et al. 2004. Cardiovasc. Res. 63, 51.
      Tanaka, A., et al. 2004. Blood 105, 2324.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-April-2008 JSW
      SynonymsN-(3,5-Bis-trifluoromethylphenyl)-5-chloro-2-hydroxybenzamide, IMD-0354
      DescriptionA cell-permeable IKK-2 inhibitor that selectively blocks IκBα phosphorylation (IC50 ~250 nM) and prevents the induction of NF-κB p65 nuclear translocation. Reported to suppress neoplastic proliferation of mast cells with constitutively activated c-kit receptor. Shown to offer cardioprotection by reducing IL-1β and MCP-1 production (IC50 <1 µM) in cardiomyocytes, and ameliorate insulin resistance in diabetic KKAy mice by regulating adiponectin release.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number978-62-1
      Chemical formulaC₁₅H₈ClF₆NO₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml) or Ethanol (1 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesKamon, J., et al. 2004. Biochem. Biophys. Res. Commun. 323, 242.
      Onai, Y., et al. 2004. Cardiovasc. Res. 63, 51.
      Tanaka, A., et al. 2004. Blood 105, 2324.