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01-201 Heregulin-β3, Epidermal growth factor (EGF) domain

The Heregulin-β3 protein, Epidermal growth factor (EGF) domain is available in a 100 µg format.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Key Applications: Cell Culture UniProt Number: Q1549, Q02297 Entrez Gene Number: NM_004495.2, NM_013956.2, NM_013957.2, NM_013958.2, NM_013959.2, NM_013960.2, NM_013961.2, NM_013962.2, NM_013964.2
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01-201
100 µg  
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      Overview

      Key Spec Table

      Key ApplicationsSource
      CULTThrombin cleaved GST-fusion protein corresponding to the EGF domain (residues 178-241) of heregulin-beta 3.
      Description
      Catalogue Number01-201
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionHeregulin-β3, Epidermal growth factor (EGF) domain
      Product Information
      PresentationPBS with 30% glycerol. Liquid.
      Quality LevelMQ100
      Applications
      ApplicationThe Heregulin-β3 protein, Epidermal growth factor (EGF) domain is available in a 100 µg format.
      Key Applications
      • Cell Culture
      Biological Information
      SourceThrombin cleaved GST-fusion protein corresponding to the EGF domain (residues 178-241) of heregulin-beta 3.
      Entrez Gene Number
      Entrez Gene SummaryNeuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentialtion of epithelial, neuronal, glial, and other types of cells.
      Gene Symbol
      • NRG1
      • NDF
      • HRG
      • Pro-NRG1
      • HRGA
      • HRG1
      • SMDF
      • GGF2
      • HGL
      • ARIA
      • GGF
      Purification MethodSterilized through a 0.2 micron membrane filter
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q15491 # The isoform SMDF may play a role in motor and sensory neuron development.| Q02297 # Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vessicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart.
      SIZE: 296 amino acids; 31686 Da
      SUBCELLULAR LOCATION: Secreted. Note=May possess an internal uncleaved signal sequence.
      TISSUE SPECIFICITY: Expressed in nervous system: spinal cord motor neurons, dorsal root ganglion neurons, and brain. Predominant isoform expressed in sensory and motor neurons. Not detected in adult heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Not expressed in fetal lung, liver and kidney.DEVELOPMENTAL STAGE: Highly expressed in developing spinal motor neurons and in developing cranial nerve nuclei. Expression is maintained only in both adult motor neurons and dorsal root ganglion neurons.
      DOMAIN: SwissProt: Q15491
      DISEASE: SwissProt: Q02297 # A rare chromosomal aberration involving NRG1 produces gamma-heregulin. Translocation t(8;11) with ODZ4. The translocation fuses the 5'-end of ODZ4 to NRG1 (isoform 8). The product of this translocation was first thought to be an alternatively spliced isoform. Gamma-heregulin is a soluble activating ligand for the ERBB2-ERBB3 receptor complex and acts as an autocrine growth factor in a specific breast cancer cell line (MDA-MB-175). Not detected in breast carcinoma samples, including ductal, lobular, medullary, and mucinous histological types, neither in other breast cancer cell lines.
      SIMILARITY: SwissProt: Q15491 ## Belongs to the neuregulin family. & Contains 1 EGF-like domain. | Q02297 # The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity). & ERBB receptor binding is elicited entirely by the EGF-like domain.# Belongs to the neuregulin family. & Contains 1 EGF-like domain. & Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
      Stem Cell Type
      • Mesenchymal Stem Cells
      • Cardiac Stem Cells
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by Receptor Activation Analysis.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Packaging Information
      Material Size100 µg
      Global Trade Item Number
      Catalogue Number GTIN
      01-201 04053252330797