505276 Sigma-AldrichHSP70 Activator II, YM-08 - CAS 1427472-76-1 - Calbiochem
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Primary Target:
HSP70
MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: (2Z,5E)-3-ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-2-(pyridin-2-ylmethylene)thiazolidin-4-one, Heat Shock 70 kDa Protein Activator II, Hsp70 Chemical Co-Chaperone II, YM-08, YM08, YM8
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Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 1427472-76-1 | C₁₉H₁₇N₃OS₂ |
Pricing & Availability
| Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
|---|---|---|---|---|---|---|
| 5.05276.0001 |
|
Glass bottle | 10 mg |
|
— |
| Description | |
|---|---|
| Overview | A cell-permeable, neutrally charged, pyridinium-to-pyridine substituted YM-01 (Cat. No. 500615) and MKT-077 structural analog that exhibits higher HSP70-binding affinity, but reduced tau degradation-promoting potency in cultures (% degradation of p-tau/total tau = 42/64, 88/89, and 81/80 in HeLaC3 with 30 µM YM-08, MKT-077, or YM-01, respectively) and weaker anti-cancer activity (IC50 against MDA-MB-231/MCF10A/MCF7 in µM = 1.4/3.0/2,2/MKT-077, 2.0/3.3/5.2/YM-01, and 8.5/7.8/10.5/YM-08 in 72 h). |
| Catalogue Number | 505276 |
| Brand Family | Calbiochem® |
| Synonyms | (2Z,5E)-3-ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-2-(pyridin-2-ylmethylene)thiazolidin-4-one, Heat Shock 70 kDa Protein Activator II, Hsp70 Chemical Co-Chaperone II, YM-08, YM08, YM8 |
| References | |
|---|---|
| References | Miyata, Y., et al. 2013. ACS Chem. Neurosci. 4, 930. |
| Product Information | |
|---|---|
| CAS number | 1427472-76-1 |
| Form | Orange solid |
| Hill Formula | C₁₉H₁₇N₃OS₂ |
| Chemical formula | C₁₉H₁₇N₃OS₂ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | HSP70 |
| Primary Target IC<sub>50</sub> | 0.6uM |
| Purity | ≥99% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 5.05276.0001 | 04055977263534 |