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345805 Geldanamycin, Streptomyces hygroscopicus - CAS 30562-34-6 - Calbiochem

A benzoquinoid antibiotic that inhibits p60c-src tyrosine kinase and c-myc gene expression in murine lymphoblastoma cells.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: pc60c-svc tyrosine kinase
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      30562-34-6C₂₉H₄₀N₂O₉
      Description
      OverviewA benzoquinoid antibiotic that inhibits p60c-src tyrosine kinase and c-myc gene expression in murine lymphoblastoma cells. Geldanamycin has antiproliferative and antitumor effects. Rapidly depletes p185c-erbB2 protein tyrosine kinase in breast carcinoma cells. Binds to HSP90 and disrupts Raf1-HSP90 complex leading to destabilization of Raf1. Inhibits basal and hypoxia-induced expression of c-Jun (IC50 = 75 nM) and abolishes hypoxia-induced increase in c-Jun N-terminal kinase activity. Also known to selectively destabilize mutated p53 protein from a number of breast, leukemia, and prostate cell lines.
      Catalogue Number345805
      Brand Family Calbiochem®
      References
      ReferencesVasilevskaya, I.A., and O’Dwyer, P.J. 1999. Cancer Res. 59, 3935.
      Mimnaugh, E.G., et al. 1996. J. Biol. Chem. 271, 22796.
      Schulte, T.W., et al. 1996. Mol. Cell. Biol. 16, 5839.
      Blagosklonny, M.V., et al. 1995. Oncogene 11, 933.
      Schnur, R.C., et al. 1995. J. Med. Chem. 38, 3806.
      Whitesell, L., et all. 1994. Proc. Natl. Acad. USA 91, 8324.
      Yamaki, H., et al. 1989. J. Antibiot. 42, 604.
      Uehara, Y., et al. 1984. Mol. Cell. Biol. 6, 2198.
      Product Information
      CAS number30562-34-6
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₂₉H₄₀N₂O₉
      Chemical formulaC₂₉H₄₀N₂O₉
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetpc60c-svc tyrosine kinase
      Primary Target IC<sub>50</sub>75 nM Inhibiting basal and hypoxia-induced expression of c-Jun
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSLX8920000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      345805 0

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Geldanamycin, Streptomyces hygroscopicus - CAS 30562-34-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Geldanamycin, Streptomyces hygroscopicus - CAS 30562-34-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      345805

      References

      Reference overview
      Vasilevskaya, I.A., and O’Dwyer, P.J. 1999. Cancer Res. 59, 3935.
      Mimnaugh, E.G., et al. 1996. J. Biol. Chem. 271, 22796.
      Schulte, T.W., et al. 1996. Mol. Cell. Biol. 16, 5839.
      Blagosklonny, M.V., et al. 1995. Oncogene 11, 933.
      Schnur, R.C., et al. 1995. J. Med. Chem. 38, 3806.
      Whitesell, L., et all. 1994. Proc. Natl. Acad. USA 91, 8324.
      Yamaki, H., et al. 1989. J. Antibiot. 42, 604.
      Uehara, Y., et al. 1984. Mol. Cell. Biol. 6, 2198.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure

      Citations

      Title
    • Dylan T. Jones, et al. (2004) Geldanamycin and herbimycin A induce apoptotic killing of B chronic lymphocytic leukemia cells and augment the cells' sensitivity to cytotoxic drugs. Blood 103, 1855-1861.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-June-2008 RFH
      DescriptionA benzoquinoid antibiotic that is a potent inhibitor of pp60src tyrosine kinase. Geldanamycin has antiproliferative and antitumor effects. Inhibits basal and hypoxia-induced expression of c-Jun (IC50 = 75 nM) and abolishes hypoxia-induced increase in c-Jun N-terminal Kinase activity. Binds to HSP90 and disrupts raf1-HSP90 complex leading to destabilizing of Raf1. Also destabilizes mutant p53 protein from a number of breast, leukemic, and prostate cell lines. Inhibits c-myc expression in murine lymphoblastoma cells. Approximately ten-fold more potent than herbimycin A (Cat. No. 375670).
      FormYellow solid
      CAS number30562-34-6
      RTECSLX8920000
      Chemical formulaC₂₉H₄₀N₂O₉
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (1 mg/ml). Further dilute with aqueous buffers just prior to use.
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesVasilevskaya, I.A., and O’Dwyer, P.J. 1999. Cancer Res. 59, 3935.
      Mimnaugh, E.G., et al. 1996. J. Biol. Chem. 271, 22796.
      Schulte, T.W., et al. 1996. Mol. Cell. Biol. 16, 5839.
      Blagosklonny, M.V., et al. 1995. Oncogene 11, 933.
      Schnur, R.C., et al. 1995. J. Med. Chem. 38, 3806.
      Whitesell, L., et all. 1994. Proc. Natl. Acad. USA 91, 8324.
      Yamaki, H., et al. 1989. J. Antibiot. 42, 604.
      Uehara, Y., et al. 1984. Mol. Cell. Biol. 6, 2198.
      Citation
    • Dylan T. Jones, et al. (2004) Geldanamycin and herbimycin A induce apoptotic killing of B chronic lymphocytic leukemia cells and augment the cells' sensitivity to cytotoxic drugs. Blood 103, 1855-1861.
      		•