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371818 G-Protein βγ Binding Peptide, mSIRK - Calbiochem

A cell-permeable, N-myristoylated G-protein βγ selective binding peptide that disrupts the interaction between α and βγ subunits and promotes the α subunit dissociation without stimulating nucleotide

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Synonyms: mSIRK, myr-SIRKALNILGYPDYD-OH

Primary Target: N-myristoylated G-protein βγ selective binding
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371818
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Overview

Key Spec Table

Empirical Formula
C₉₃H₁₅₀N₂₀O₂₅

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371818-1MG
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      371818-5MG
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          Description
          OverviewA cell-permeable, N-myristoylated G-protein βγ selective binding peptide that disrupts the interaction between α and βγ subunits and promotes the α subunit dissociation without stimulating nucleotide exchange. Shown to cause a rapid activation of ERK1/2 (EC50 ~ 2.5 - 5 µM) in rat arterial smooth muscle and Rat2 cells. Also promotes the phosphorylation of JNK and p38 MAP kinase, phospholipase C and causes Ca2+ release from internal stores. Negative control is also available (Cat. No. 371820).
          Catalogue Number371818
          Brand Family Calbiochem®
          SynonymsmSIRK, myr-SIRKALNILGYPDYD-OH
          References
          ReferencesGoubaeva, F., et al. 2003. J. Biol. Chem. 278, 19634.
          Scott, J.K., et al. 2001. EMBO J. 20, 767.
          Product Information
          ATP CompetitiveN
          FormLyophilized
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₉₃H₁₅₀N₂₀O₂₅
          Chemical formulaC₉₃H₁₅₀N₂₀O₂₅
          Hygroscopic Hygroscopic
          ReversibleN
          Quality LevelMQ100
          Biological Information
          Primary TargetN-myristoylated G-protein βγ selective binding
          Primary Target IC<sub>50</sub>EC50 ~ 2.5 - 5 µM in activation of ERK1/2 in rat arterial smooth muscle and Rat2 cells
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceMyr-N-Ser-Ile-Arg-Lys-Ala-Leu-Asn-Ile-Leu-Gly-Tyr-Pro-Asp-Tyr-Asp-OH
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Global Trade Item Number
          Catalogue Number GTIN
          371818-1MG 04055977213423
          371818-5MG 04055977213430