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344931 Furin Inhibitor II - Calbiochem

The Furin Inhibitor II controls the biological activity of Furin. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Furin Inhibitor II - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Hexa-D-arginine, H-(D)RRRRRR-NH₂

Primary Target: furin
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344931
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Overview

Key Spec Table

Empirical Formula
C₃₆H₇₅N₂₅O₆

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344931-1MG
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      Description
      OverviewA polyarginine compound that acts as a potent, specific, and competitive inhibitor of furin (Ki = 106 nM). Inhibits Subtilisin-like proprotein convertase 4 (PACE4) and prohormone convertase 1 (PC1) at much higher concentration (Ki = 580 nM and 13 µM, respectively). Has a stimulatory effect on the activity of prohormone convertase 2 (PC2). The D-peptides are suggested to be more resistant to in vivo hydrolysis than L-peptides.
      Catalogue Number344931
      Brand Family Calbiochem®
      SynonymsHexa-D-arginine, H-(D)RRRRRR-NH₂
      References
      ReferencesCameron, A., et al. 2000. J. Biol. Chem. 275, 36741.
      Product Information
      ATP CompetitiveY
      FormWhite solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₃₆H₇₅N₂₅O₆
      Chemical formulaC₃₆H₇₅N₂₅O₆
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Biological Information
      Primary Targetfurin
      Primary Target K<sub>i</sub>106 nM against Furin
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceH-(D)Arg-Arg-Arg-Arg-Arg-Arg-NH₂
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      344931-1MG 04055977194395