Millipore Sigma Vibrant Logo

344282 Forskolin, Coleus forskohlii in DMSO - Calbiochem

The major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
View Products on Sigmaaldrich.com
344282
View Pricing & Availability

Overview

Key Spec Table

Empirical Formula
C₂₂H₃₄O₇

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
344282-5MG
—
Limited Availability Limited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      		 Glass bottle 5 mg
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      —
      Request Pricing
      		 —
      Add To Favorites
      Description
      OverviewThe major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii. At low doses, it acts as a positive inotropic agent. At higher doses, it serves as a hypotensive and vasodilatory agent due to its actions as a smooth muscle relaxant. No major side effects are observed at effective doses. Forskolins pharmacological activities are due to its activation of adenylate cyclase (EC50 = 4 µM), resulting in increased cAMP levels. The exact mechanism of forskolins positive inotropic effect is unknown but may be related to a cAMP-dependent increase in Na+ permeability that results in indirect augmentation of Ca2+ release. Inhibits MAP kinase in rat renal mesangial cells (IC50 = 25 µM). Also acts as a Hh pathway antagonist. Shown to inhibit apoptosis in cerebellar granule cells and to induce apoptosis in resting human B lymphocytes. The solid form of this compound (Cat. No. 344270) is also available.
      Catalogue Number344282
      Brand Family Calbiochem®
      References
      ReferencesD'Orazio, J.A., et al. 2006. Nature 443, 340.
      Noveen, A., et al. 1996. Biochem. Biophys. Res. Commun. 219, 180.
      Galli, C., et al. 1995. J. Neurosci. 15, 1172.
      Li, X., et al. 1995. Am. J. Physiol. 269, C986.
      Lomo, J., et al. 1995. J. Immunol. 154, 1634.
      Uneyama, H., et al. 1993. J. Biol. Chem. 268, 168.
      Laurenza, A., et al. 1989. Trends Pharmacol. Sci. 10, 442.
      Adashi, E.Y., and Resnick, C.E. 1986. J. Cell. Biochem. 31, 217.
      Seamon, K.B., and Daly, J.W. 1986. Adv. Cyclic Nucleotide Protein Phosphorylation Res. 20, 1.
      Huang, R., et al. 1982. Cyclic Nucleotide Res. 8, 385.
      Metzger, H., and Lindner, E. 1981. IRCS Med. Sci. Biochem. Cardiovasc. System Pharmacol. 9, 99.
      Product Information
      FormLiquid
      FormulationA 50 mM (5 mg/244 µl) solution of Forskolin, Coleus forskohlii (Cat. No. 344270) in DMSO.
      Hill FormulaC₂₂H₃₄O₇
      Chemical formulaC₂₂H₃₄O₇
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥97% by HPLC
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 26-36-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      344282-5MG 04055977214680