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343290 Fluoxetine, Hydrochloride - CAS 56296-78-7 - Calbiochem

A cell-permeable phenylpropylamine derived anti-depressant that acts as a selective serotonin re-uptake inhibitor (SSRI).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: dl-N-Methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine, HCl, (±)-N-Methyl-3-phenyl-3-[(α,α,α-trifluoro-p-tolyl)oxy]propylamine, HCl, LY-110140, Prozac

Primary Target: Selective serotonin re-uptake inhibitor
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343290
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Overview

Key Spec Table

CAS #Empirical Formula
56296-78-7C₁₇H₁₈F₃NO • HCL

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343290-25MG
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      Description
      OverviewA cell-permeable phenylpropylamine derived anti-depressant that acts as a selective serotonin re-uptake inhibitor (SSRI). Reported to modulate the proliferation of T-cells by increasing the Ca2+ influx and thereby influencing the activities of protein kinase A (PKA) and protein kinase C (PKC). Also shown to regulate the phosphorylation of DARPP-32 (dopamine-and cAMP-regulated phosphoprotein of Mr 32,000) and AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors. Shown to trigger oxidative stress-induced apoptotic cell death. Also reported to initiate signaling pathways in neuronal cells leading to activation of ERK and NF-κB.
      Catalogue Number343290
      Brand Family Calbiochem®
      Synonymsdl-N-Methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine, HCl, (±)-N-Methyl-3-phenyl-3-[(α,α,α-trifluoro-p-tolyl)oxy]propylamine, HCl, LY-110140, Prozac
      References
      ReferencesBartholoma, P., et al. 2002. Biochem. Pharmacol. 63, 1507.
      Bian, J.T., et al. 2002. Eur. J. Pharmacol. 453, 159.
      Zhang, A., et al. 2002. J. Med. Chem. 45, 1930.
      Svenningsson, P., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 3182.
      Edgar, V.A., et al. 1999. Eur. J. Pharmacol. 372, 65.
      Product Information
      CAS number56296-78-7
      ATP CompetitiveN
      FormSolid
      Hill FormulaC₁₇H₁₈F₃NO • HCL
      Chemical formulaC₁₇H₁₈F₃NO • HCL
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetSelective serotonin re-uptake inhibitor
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      343290-25MG 04055977195101