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344550 FTI-276 - Calbiochem

A highly potent and selective CAAX peptidomimetic of the carboxyl terminal of Ras proteins that inhibits farnesyl transferase (FTase) in vitro (IC₅₀ = 500 pM).

FTI-276 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-[2-phenyl-4-N[2(R)-amino-3-mercaptopropylamino benzoyl]-methionine, TFA

Primary Target: FTase in vitro
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344550
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Overview

Key Spec Table

Empirical Formula
C₂₁H₂₇N₃O₃S₂

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344550-250UG
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      		 Plastic ampoule 250 μg
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      Description
      OverviewA highly potent and selective CAAX peptidomimetic of the carboxyl terminal of Ras proteins that inhibits farnesyl transferase (FTase) in vitro (IC50 = 500 pM). Inhibits geranylgeranyltransferase I (GGTase I) at much higher concentration (IC50 = 50 nM). Has been shown to selectively block the growth of a human lung carcinoma expressing oncogenic K-Ras in nude mice. Also inhibits oncogenic signaling and tumor growth of NIH 3T3 cells transformed with the Ras oncogene at 20 µM.
      Catalogue Number344550
      Brand Family Calbiochem®
      SynonymsN-[2-phenyl-4-N[2(R)-amino-3-mercaptopropylamino benzoyl]-methionine, TFA
      References
      ReferencesLantry, L.E., et al. 2000. Carcinogenesis 21, 113.
      Lerner, E.C., et al. 1995. J. Biol. Chem. 270, 26802.
      Sun, J., et al. 1995. Cancer Res. 55, 4243.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₂₁H₂₇N₃O₃S₂
      Chemical formulaC₂₁H₂₇N₃O₃S₂
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetFTase in vitro
      Primary Target IC<sub>50</sub>500 pM against FTase in vitro
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableN
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 1 week at -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      344550-250UG 04055977214765