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325001 Epothilone B, Synthetic

A structural analog of Epothilone A with similar biological properties.

Epothilone B, Synthetic MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: EpoB

Primary Target: P-glycoprotein-expressing multidrug resistant (MDR) cells
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      152044-54-7C₂₇H₄₁NO₆S
      Description
      Overview

      This product has been discontinued.



      A structural analog of Epothilone A (Cat. No. 325000) with similar biological properties. However, EpoB is about 10-fold more potent than EpoA against P-glycoprotein-expressing multidrug resistant (MDR) cells (IC50 = 2 nM for MDR CCRF-CEM/VBL100 cells).
      Catalogue Number325001
      Brand Family Calbiochem®
      SynonymsEpoB
      References
      ReferencesGiannakakou, P., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2904.
      Chou, T.-C., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 9642.
      Kowalski, R.J., et al. 1997. J. Biol. Chem. 272, 2534.
      Muhlradt, P.F., and Sasse, F. 1997. Cancer Res. 57, 3344.
      Nicolaou, K.C., et al. 1997. Nature 387, 268.
      Bollag, D.M., et al. 1995. Cancer Res. 55, 2325.
      Product Information
      CAS number152044-54-7
      ATP CompetitiveN
      DeclarationNot available for sale in Germany.
      FormWhite to off-white solid
      Hill FormulaC₂₇H₄₁NO₆S
      Chemical formulaC₂₇H₄₁NO₆S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetP-glycoprotein-expressing multidrug resistant (MDR) cells
      Primary Target IC<sub>50</sub>2 nM for MDR CCRF-CEM/VBL100 cells
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 23/24/25-37/38-41-46-60

      Toxic by inhalation, in contact with skin and if swallowed.
      Irritating to respiratory system and skin.
      Risk of serious damage to eyes.
      May cause heritable genetic damage.
      May impair fertility.
      S PhraseS: 22-26-36/37/39-45

      Do not breathe dust.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic & Carcinogenic / Teratogenic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      325001 0

      Documentation

      Epothilone B, Synthetic SDS

      Title

      Safety Data Sheet (SDS) 

      Epothilone B, Synthetic Certificates of Analysis

      TitleLot Number
      325001

      References

      Reference overview
      Giannakakou, P., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2904.
      Chou, T.-C., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 9642.
      Kowalski, R.J., et al. 1997. J. Biol. Chem. 272, 2534.
      Muhlradt, P.F., and Sasse, F. 1997. Cancer Res. 57, 3344.
      Nicolaou, K.C., et al. 1997. Nature 387, 268.
      Bollag, D.M., et al. 1995. Cancer Res. 55, 2325.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-December-2018 JSW
      SynonymsEpoB
      DescriptionA structural analog of Epothilone A (Cat. No. 325000) with similar biological properties. However, EpoB is about 10-fold more potent than EpoA against P-glycoprotein-expressing multi drug resistant (MDR) cells (IC50 = 2 nM for MDR CCRF-CEM/VBL100 cells).
      FormWhite to off-white solid
      CAS number152044-54-7
      Chemical formulaC₂₇H₄₁NO₆S
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
      Toxicity Toxic & Carcinogenic / Teratogenic
      ReferencesGiannakakou, P., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2904.
      Chou, T.-C., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 9642.
      Kowalski, R.J., et al. 1997. J. Biol. Chem. 272, 2534.
      Muhlradt, P.F., and Sasse, F. 1997. Cancer Res. 57, 3344.
      Nicolaou, K.C., et al. 1997. Nature 387, 268.
      Bollag, D.M., et al. 1995. Cancer Res. 55, 2325.