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500713 EphA Antagonist - CAS 674782-30-0 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
674782-30-0C₁₃H₁₃NO₃

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      Glass bottle 10 mg
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      Description
      OverviewA pyrrolyl benzoic acid that effectively competes against ephrin-B3 for EphA4 binding as well as against ephrin-A1/-A2/-A3/-A5 for EphA2 and EphA4 binding by targeting EphA2/A4 high affinity ephrin-binding pocket in a reversible manner, exhibiting much reduced or no potency against ephrin-A4 for EphA2/EphA4 binding, ephrin-A5 for EphA3/A5/A6/A7 binding, ephrin-B2 for B1/B2/B3/B4/B6 binding, or ephrin-B2 for EphA4 binding. Shown to inhibit ephrin-A1-induced EphA2 phosphorylation (by 92% at 200 µM) and ephrin-A5-induced EphA4 phosphorylation (by 79% at 400 µM) in cultures in vitro and prevent ephrin-A5-induced growth cone collapse of neurons in 6-d chicken embryo retina (by 100% at 400 µM) ex vivo, as well as rescue human mutant SOD-1 A4V transgene-induced axonopathy in zebrafish embryos (500 µM from 6 to 30 hpf) in vivo.
      Catalogue Number500713
      Brand Family Calbiochem®
      SynonymsRtk2 Antagonist, Rtk1 Antagonist, 4-(2,5-dimethyl-1H-pyrrol-1-yl)-2-hydroxybenzoic acid, EphA2 Antagonist, EphA4 Antagoinst, Ephrin Receptor Antagonist
      References
      ReferencesVan Hoecke, A., et al. 2012. Nat. Med. 18, 1418.
      Noberini, R., et al. 2008. J. Biol. Chem. 283, 29461.
      Product Information
      CAS number674782-30-0
      FormOrange powder
      Hill FormulaC₁₃H₁₃NO₃
      Chemical formulaC₁₃H₁₃NO₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetEphA
      Primary Target IC<sub>50</sub>3 micro
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      5.00713.0001 04055977264227