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298711 Diethyl Pyrocarbonate - CAS 1609-47-8 - Calbiochem

Inhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle in a dose- and time-dependent manner and increases the Ca2+ permeability of SR vesicles.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Diethyl Oxydiformate, DEPC

Primary Target: Inhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle
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298711
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1609-47-8C₆H₁₀O₅

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298711-100GM
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      298711-25GM
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          Description
          OverviewInhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle in a dose- and time-dependent manner and increases the Ca2+ permeability of SR vesicles. Useful for specific inactivation of nucleases during isolation of undegraded polynucleotides. Also inhibits platelet-activating factor acetyl hydrolase. Has been used as a probe for the topography of 5.8S rRNA in yeast ribosomes.
          Catalogue Number298711
          Brand Family Calbiochem®
          SynonymsDiethyl Oxydiformate, DEPC
          References
          ReferencesShoshan-Barmatz, V., and Weil, S. 1994. Biochem. J. 299, 177.
          Blumbers, D.O. 1987. Methods Enzymol. 152, 20.
          Product Information
          CAS number1609-47-8
          ATP CompetitiveN
          FormClear colorless liquid
          Hill FormulaC₆H₁₀O₅
          Chemical formulaC₆H₁₀O₅
          ReversibleN
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetInhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle
          Purity≥96% by titration
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSLQ9350000
          Safety Information
          R PhraseR: 22-36/37/38

          Harmful if swallowed.
          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          298711-100GM 04055977197952
          298711-25GM 07790788049041

          Documentation

          Diethyl Pyrocarbonate - CAS 1609-47-8 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Diethyl Pyrocarbonate - CAS 1609-47-8 - Calbiochem Certificates of Analysis

          TitleLot Number
          298711

          References

          Reference overview
          Shoshan-Barmatz, V., and Weil, S. 1994. Biochem. J. 299, 177.
          Blumbers, D.O. 1987. Methods Enzymol. 152, 20.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-October-2019 JSW
          SynonymsDiethyl Oxydiformate, DEPC
          DescriptionInhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle. Useful for specific inactivation of nucleases during isolation of undegraded polynucleotides. Also inhibits platelet-activating factor acetyl hydrolase. Has been used as a probe for the topography of 5.8S rRNA in yeast ribosomes.
          FormClear colorless liquid
          CAS number1609-47-8
          RTECSLQ9350000
          Chemical formulaC₆H₁₀O₅
          Purity≥96% by titration
          SolubilityChloroform or Ethanol
          Storage Protect from light
          +2°C to +8°C
          Do Not Freeze Ok to freeze
          Toxicity Harmful
          Merck USA index14, 7998
          ReferencesShoshan-Barmatz, V., and Weil, S. 1994. Biochem. J. 299, 177.
          Blumbers, D.O. 1987. Methods Enzymol. 152, 20.