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407141 D-myo-Inositol 1,3,5-Trisphosphate Hexakisacetoxymethyl Ester, 2,4,6-Tri-O-butyryl-, - Calbiochem

D-myo-Inositol 1,3,5-Trisphosphate Hexakisacetoxymethyl Ester, 2,4,6-Tri-O-butyryl- is a cell-permeable derivative of Ins(1,3,5)P3.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Bt₃(1,3,5)IP₃/AM

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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₃₆H₅₇O₃₀P₃
      Description
      Overview

      This product has been discontinued.



      A cell-permeable derivative of D-myo-inositol 1,3,5-trisphosphate [Ins(1,3,5)P3].
      Note: Each set contains 1 µmol Bt3(1,3,5)IP3/AM and 10 mg PLURONIC® F-127 detergent (Cat. No. 540025) to aid in the solubilization of this product.
      Catalogue Number407141
      Brand Family Calbiochem®
      SynonymsBt₃(1,3,5)IP₃/AM
      References
      ReferencesRudolf, M.T., et al. 2003. Bioorg. Med. Chem. 11, 3315.
      Product Information
      ATP CompetitiveN
      FormClear syrup
      Formulation1 µmol Bt₃(1,3,5)IP₃/AM and 10 mg PLURONIC® F-127 detergent.
      Hill FormulaC₃₆H₅₇O₃₀P₃
      Chemical formulaC₃₆H₅₇O₃₀P₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationD-myo-Inositol 1,3,5-Trisphosphate Hexakisacetoxymethyl Ester, 2,4,6-Tri-O-butyryl- is a cell-permeable derivative of Ins(1,3,5)P3.
      Biological Information
      Primary TargetA cell-permeable derivative of D-myo-inositol 1,3,5-trisphosphate [Ins(1,3,5)P3]
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution of IPx, aliquot and freeze (-20°C). Stock solutions of IPx are stable for up to 3 months. Following reconstitution of PLURONIC® F-127 detergent, refrigerate (4°C). DO NOT FREEZE!
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      407141 0

      Documentation

      D-myo-Inositol 1,3,5-Trisphosphate Hexakisacetoxymethyl Ester, 2,4,6-Tri-O-butyryl-, - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      D-myo-Inositol 1,3,5-Trisphosphate Hexakisacetoxymethyl Ester, 2,4,6-Tri-O-butyryl-, - Calbiochem Certificates of Analysis

      TitleLot Number
      407141

      References

      Reference overview
      Rudolf, M.T., et al. 2003. Bioorg. Med. Chem. 11, 3315.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-February-2008 JSW
      SynonymsBt₃(1,3,5)IP₃/AM
      DescriptionNovel analogs capable of exhibiting Ins(1,4,5)P3-like agonist or antagonist effects on calcium release are more resistant to hydrolysis and metabolic degradation than IP3 or IP4. Consequently, they can produce a prolonged activation of cellular processes dependent on the Ins(1,4,5)P3 receptor interaction. These tools are important in the elucidation of the molecular interactions of Ins(1,4,5)P3 with its intracellular receptor and with Ins(1,4,5)P3-kinase and 5-phosphatase. Acetoxymethyl esters of inositol phosphate are highly lipophilic. Hence, they easily diffuse through the cell membrane. Note: Each set contains 1 µmol of Bt3(1,3,5)IP3/AM and 10 mg of PLURONIC® F-127 detergent (Cat. No. 540025) to aid in the solubilization of this product.
      FormClear syrup
      Formulation1 µmol Bt₃(1,3,5)IP₃/AM and 10 mg PLURONIC® F-127 detergent.
      Intert gas (Yes/No) Packaged under inert gas
      Recommended reaction conditions
      Protocol for Treating Cells with IPx 1. Add 10 µl DMSO to 1 µmol Bt3(1,3,5)IP3/AM to make a 100 mM stock solution. 2. Prepare a 10% PLURONIC® F-127 solution in DMSO. DO NOT FREEZE! 3. Obtain 1 ml uniform cell suspension and place 500 µl of the suspension in a test tube. 4. Add 1 µl of the DMSO/Bt3(1,3,5)IP3/AM solution (step 1) and 2 µl of the 10% PLURONIC®/DMSO stock solution (step 2) to the cell suspension in step 3 and mix. 5. Add the cells/Bt3(1,3,5)IP3/AM /PLURONIC® mixture from step 4 to a tube containing the remaining 500 µl cell suspension. Mix carefully. The total test-tube volume now equals 1 ml.
      Chemical formulaC₃₆H₅₇O₃₀P₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (IPx, 100 mM; PLURONIC® F-127 detergent, 100 mg/ml)
      Storage Protect from moisture
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution of IPx, aliquot and freeze (-20°C). Stock solutions of IPx are stable for up to 3 months. Following reconstitution of PLURONIC® F-127 detergent, refrigerate (4°C). DO NOT FREEZE!
      Toxicity Standard Handling
      ReferencesRudolf, M.T., et al. 2003. Bioorg. Med. Chem. 11, 3315.