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238590
Sigma-AldrichCucurbitacin I, Cucumis sativus L. - CAS 2222-07-3 - Calbiochem
Cucurbitacin I, Cucumis sativus L., CAS 2222-07-3, is a cell-permeable anti-proliferative agent that acts as a potent and highly selective inhibitor of JAK/STAT3 signaling pathway.
More>>Cucurbitacin I, Cucumis sativus L., CAS 2222-07-3, is a cell-permeable anti-proliferative agent that acts as a potent and highly selective inhibitor of JAK/STAT3 signaling pathway. Less<<
MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Description
Overview
A cell-permeable and irreversible bitter triterpenoid compound (NCI identifier: NSC 521777) that displays anti-proliferative and antitumor properties both in vitro and in vivo. Acts as a potent and highly selective inhibitor of Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) signaling pathway. It suppresses STAT3 tyrosine phosphorylation in v-Src-transformed NIH 3T3 cells and human lung adenocarcinoma A549 cells (IC50 = 500 nM), resulting in inhibition of STAT3 DNA-binding and STAT3-mediated gene transcription. Shown to inhibit the growth of STAT3-transformed tumors in nude mice. Does not affect oncogenic pathways mediated by Ras, Akt, Erk1/2, or JNK.
Catalogue Number
238590
Brand Family
Calbiochem®
Synonyms
JSI-124, STAT3 Inhibitor XIV
References
References
Blaskovich, M.A., et al. 2003. Cancer Res.63, 1270.
Cucurbitacin I, Cucumis sativus L., CAS 2222-07-3, is a cell-permeable anti-proliferative agent that acts as a potent and highly selective inhibitor of JAK/STAT3 signaling pathway.
Biological Information
Primary Target
JAK/STAT3
Primary Target IC<sub>50</sub>
500 nM suppressing STAT3 tyrosine phosphorylation in v-Src-transformed NIH 3T3 cells and human lung adenocarcinoma A549 cells
Purity
≥95% by HPLC
Physicochemical Information
Cell permeable
Y
Safety Information according to GHS
RTECS
RC6200000
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Standard Handling
Storage
-20°C
Protect from Light
Protect from light
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas
Packaged under inert gas
Global Trade Item Number
Catalogue Number
GTIN
238590-1MG
04055977216592
Documentation
Cucurbitacin I, Cucumis sativus L. - CAS 2222-07-3 - Calbiochem SDS
Cucurbitacin I, Cucumis sativus L. - CAS 2222-07-3 - Calbiochem Certificates of Analysis
Title
Lot Number
238590
References
Reference overview
Blaskovich, M.A., et al. 2003. Cancer Res.63, 1270.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
21-April-2011 JSW
Synonyms
JSI-124, STAT3 Inhibitor XIV
Description
A cell-permeable and irreversible bitter triterpenoid compound (NCI identifier: NSC 521777) that exhibits anti-proliferative and anti-tumor properties both in vitro and in vivo. Acts as a potent and highly selective inhibitor of Janus kinase/Signal transducer and activator of transcription 3 (Jak/STAT3) signaling pathway. Reported to suppress STAT3 tyrosine phosphorylation in v-src-transformed NIH 3T3 cells and human lung adenocarcinoma A549 cells (IC50 = 500 nM), resulting in inhibition of STAT3 DNA-binding and STAT3-mediated gene transcription. Also shown to inhibit the growth of STAT3-transformed tumors in nude mice. Does not affect oncogenic pathways mediated by Ras, Akt1, ERK1/2, or JNK.
Form
White solid
Intert gas (Yes/No)
Packaged under inert gas
CAS number
2222-07-3
RTECS
RC6200000
Chemical formula
C₃₀H₄₂O₇
Structure formula
Purity
≥95% by HPLC
Solubility
DMSO (100 mg/ml) or Ethanol (10 mg/ml)
Storage
Protect from light -20°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Standard Handling
References
Blaskovich, M.A., et al. 2003. Cancer Res.63, 1270.
