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342000 Caspase Inhibitor, Negative Control - CAS 105637-38-5 - Calbiochem

The Caspase Inhibitor, Negative Control, also referenced under CAS 105637-38-5, controls the biological activity of Caspase. This small molecule/inhibitor is primarily used for Cancer applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Z-FA-FMK, Cathepsin B, Inhibitor I

Primary Target: Cathepsin-B
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      Overview

      Key Spec Table

      CAS #Empirical Formula
      105637-38-5C₂₁H₂₃FN₂O₄
      Description
      OverviewA cell-permeable, irreversible cathepsin B inhibitor. Blocks LPS-induced production of IL-1α and IL-1β. Suitable as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position.
      Catalogue Number342000
      Brand Family Calbiochem®
      SynonymsZ-FA-FMK, Cathepsin B, Inhibitor I
      References
      ReferencesSchotte, P., et al. 2001. J. Biol. Chem. 276, 21153.
      Guo, H., et al. 1998. Exp. Cell Res. 245, 57.
      Rosenthal, P.J., et al. 1993. J. Clin. Invest. 91, 1057.
      Ahmed, N.K., et al. 1992. Biochem. Pharmacol. 44, 1201.
      Rauber, P., et al. 1986. Biochem. J. 239, 633.
      Shaw, E., et al. 1986. Biomed. Biochim. Acta 45, 1397.
      Rasnick, D. 1985. Anal. Biochem. 149, 461.
      Product Information
      CAS number105637-38-5
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₂₁H₂₃FN₂O₄
      Chemical formulaC₂₁H₂₃FN₂O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetCathepsin-B
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceZ-Phe-Ala-FMK
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      342000 0