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217386 Carboxy-PTIO, Sodium Salt - Calbiochem

Reacts with nitric oxide at pH 7.4, resulting in the generation of NO2⁻/NO3⁻ with a rate constant of 1 x 10⁴ M⁻¹sec⁻¹.

Carboxy-PTIO, Sodium Salt - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide, Na

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217386
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₄H₁₆N₂O₄ · Na

Pricing & Availability

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217386-10MG
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      		 Plastic ampoule 10 mg
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      Description
      OverviewReacts with nitric oxide at pH 7.4, resulting in the generation of NO2-/NO3- with a rate constant of 1 x 104 M-1sec-1. Prevents SIN-1 induced endothelial cell death. Has potent therapeutic value in endotoxin shock through its nitric oxide scavenging action.
      Catalogue Number217386
      Brand Family Calbiochem®
      Synonyms2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide, Na
      References
      ReferencesIshii, M., et al., 1999. J. Cardiovasc. Pharmacol. 33, 295.
      Amano, F., and Nova, J. 1995. FEBS Lett. 368, 425.
      Hogg, N., et al. 1995. Free Radical Res. 22, 47.
      Az-ma, T., et al. 1994. Life Sci. 54, 185.
      Yoshida, M., et al. 1994. Biochem. Biophys. Res. Commun. 202, 923.
      Akaike, T., et al. 1993. Biochemistry 32, 827.
      Yoshida, K., et al. 1993. Infect. Immun. 61, 3552.
      Product Information
      ATP CompetitiveN
      FormDark blue solid
      Hill FormulaC₁₄H₁₆N₂O₄ · Na
      Chemical formulaC₁₄H₁₆N₂O₄ · Na
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNitric oxide scavenging action
      Purity≥97% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, refrigerate (4°C). Aqueous stock solutions are stable for up to 1 week at 4°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      217386-10MG 04055977219357

      Documentation

      Carboxy-PTIO, Sodium Salt - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Carboxy-PTIO, Sodium Salt - Calbiochem Certificates of Analysis

      TitleLot Number
      217386

      References

      Reference overview
      Ishii, M., et al., 1999. J. Cardiovasc. Pharmacol. 33, 295.
      Amano, F., and Nova, J. 1995. FEBS Lett. 368, 425.
      Hogg, N., et al. 1995. Free Radical Res. 22, 47.
      Az-ma, T., et al. 1994. Life Sci. 54, 185.
      Yoshida, M., et al. 1994. Biochem. Biophys. Res. Commun. 202, 923.
      Akaike, T., et al. 1993. Biochemistry 32, 827.
      Yoshida, K., et al. 1993. Infect. Immun. 61, 3552.

      Brochure

      Title
      Pathways and Biomarkers of Oxidative Stress
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-June-2008 RFH
      Synonyms2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide, Na
      DescriptionReacts with nitric oxide at pH 7.4, resulting in the generation of NO2-/NO3- with a rate constant of 1 x 104 M-1sec-1. Prevents SIN-1 induced endothelial cell death. Reported to have potent therapeutic value in endotoxin shock through its nitric oxide scavenging action.
      FormDark blue solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₄H₁₆N₂O₄ · Na
      Structure formulaStructure formula
      Purity≥97% by TLC
      SolubilityHEPES Buffer (0.4 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, refrigerate (4°C). Aqueous stock solutions are stable for up to 1 week at 4°C.
      Toxicity Standard Handling
      ReferencesIshii, M., et al., 1999. J. Cardiovasc. Pharmacol. 33, 295.
      Amano, F., and Nova, J. 1995. FEBS Lett. 368, 425.
      Hogg, N., et al. 1995. Free Radical Res. 22, 47.
      Az-ma, T., et al. 1994. Life Sci. 54, 185.
      Yoshida, M., et al. 1994. Biochem. Biophys. Res. Commun. 202, 923.
      Akaike, T., et al. 1993. Biochemistry 32, 827.
      Yoshida, K., et al. 1993. Infect. Immun. 61, 3552.