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220201 CHAPS, Molecular Biology Grade - CAS 75621-03-3 - Calbiochem

CAS 75621-03-3 is a zwitterionic detergent that combines features of bile salts and N-alkyl sulfobetaines.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate

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220201
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
75621-03-3C₃₂H₅₈N₂O₇S

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                          Description
                          OverviewZwitterionic detergent that combines features of bile salts and N-alkyl sulfobetaines. Better at solubilizing proteins than structurally-related carboxylic acid anions and is much more effective at breaking protein-protein interactions than either sodium cholate or TRITON® X-100 Detergent. Capable of solubilizing the opiate receptor to a state exhibiting reversible binding of opiates. Also, capable of disaggregating cytochrome P450 to its monomeric form without denaturation. Has a small micellar molecular weight and a high critical micellar concentration and can be removed from either gels or protein solutions by dialysis across a membrane. Aggregation number: 4-14.
                          Conductivity (1.0 M, 24°C): <100 µmhos.
                          Catalogue Number220201
                          Brand Family Calbiochem®
                          Synonyms3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate
                          References
                          ReferencesChen, Y., et al. 1992. Biochemistry 31, 2415.
                          Ofri, D., et al. 1992. J. Neurochem. 58, 628.
                          Ransom, R.W., et al. 1992. Biochem. Pharmacol. 43, 1823.
                          Simonds, W.F., et al. 1992. Proc. Natl. Acad. Sci. USA 77, 4623.
                          Yannariello-Brown, J., and Weigel, P.H. 1992. Biochemistry 31, 576.
                          Hjelmeland, L.M. 1980. Proc. Natl. Acad. Sci. USA 77, 6368.
                          Simonds, W.F., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 4623.
                          Product Information
                          CAS number75621-03-3
                          Aggregation Number4 - 14
                          CMC6 - 10 mM
                          FormWhite crystalline powder
                          Hill FormulaC₃₂H₅₈N₂O₇S
                          Chemical formulaC₃₂H₅₈N₂O₇S
                          Hygroscopic Hygroscopic
                          Micellar weight6150
                          Quality LevelMQ300
                          Applications
                          Biological Information
                          Purity≥98% by NMR
                          Physicochemical Information
                          ContaminantsDNase, RNase, and Protease: none detected
                          Dimensions
                          Materials Information
                          Toxicological Information
                          Safety Information according to GHS
                          Safety Information
                          R PhraseR: 22-36/38

                          Harmful if swallowed.
                          Irritating to eyes and skin.
                          S PhraseS: 26-36

                          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
                          Wear suitable protective clothing.
                          Product Usage Statements
                          Storage and Shipping Information
                          Ship Code Ambient Temperature Only
                          Toxicity Harmful
                          Storage +15°C to +30°C
                          Hygroscopic Hygroscopic
                          Do not freeze Ok to freeze
                          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
                          Packaging Information
                          Transport Information
                          Supplemental Information
                          Specifications
                          Global Trade Item Number
                          Catalogue Number GTIN
                          220201-10GM 07790788048754
                          220201-1GM 04055977200973
                          220201-1KG 04055977200980
                          220201-250GM 04055977201017
                          220201-25GM 04055977201000
                          220201-5GM 04055977201024

                          Documentation

                          CHAPS, Molecular Biology Grade - CAS 75621-03-3 - Calbiochem SDS

                          Title

                          Safety Data Sheet (SDS) 

                          CHAPS, Molecular Biology Grade - CAS 75621-03-3 - Calbiochem Certificates of Analysis

                          TitleLot Number
                          220201

                          References

                          Reference overview
                          Chen, Y., et al. 1992. Biochemistry 31, 2415.
                          Ofri, D., et al. 1992. J. Neurochem. 58, 628.
                          Ransom, R.W., et al. 1992. Biochem. Pharmacol. 43, 1823.
                          Simonds, W.F., et al. 1992. Proc. Natl. Acad. Sci. USA 77, 4623.
                          Yannariello-Brown, J., and Weigel, P.H. 1992. Biochemistry 31, 576.
                          Hjelmeland, L.M. 1980. Proc. Natl. Acad. Sci. USA 77, 6368.
                          Simonds, W.F., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 4623.

                          Brochure

                          Title
                          Biological Detergents Brochure
                          Bulk Product Guide
                          CALBIOSORBﾙ Technical Bulletin
                          Data Sheet

                          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

                          Revision12-November-2010 RFH
                          Synonyms3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate
                          DescriptionNon-denaturing zwitterionic detergent that combines features of bile salts and N-alkyl sulfobetaines. Better at solubilizing proteins than the structurally related carboxylic acid anions, and is more effective at breaking protein-protein interactions than either sodium cholate or TRITON® X-100. Capable of solubilizing the opiate receptor to a state exhibiting reversible binding to opiates. Also capable of disaggregating P 450 to its monomeric form without denaturation. Has a small micellar molecular weight (6150 Daltons) and a high critical micellar concentration (6-10 mM). Can be removed from either gels or protein solutions by dialysis. Aggregation number: 4-14.
                          FormWhite crystalline powder
                          CAS number75621-03-3
                          Chemical formulaC₃₂H₅₈N₂O₇S
                          Purity≥98% by NMR
                          ContaminantsDNase, RNase, and Protease: none detected
                          SolubilityH₂O (1.0 M)
                          Storage +15°C to +30°C
                          Hygroscopic
                          Do Not Freeze Ok to freeze
                          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
                          Toxicity Harmful
                          Merck USA index14, 2044
                          ReferencesChen, Y., et al. 1992. Biochemistry 31, 2415.
                          Ofri, D., et al. 1992. J. Neurochem. 58, 628.
                          Ransom, R.W., et al. 1992. Biochem. Pharmacol. 43, 1823.
                          Simonds, W.F., et al. 1992. Proc. Natl. Acad. Sci. USA 77, 4623.
                          Yannariello-Brown, J., and Weigel, P.H. 1992. Biochemistry 31, 576.
                          Hjelmeland, L.M. 1980. Proc. Natl. Acad. Sci. USA 77, 6368.
                          Simonds, W.F., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 4623.