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SCT244 BioTracker Dual-Color Mitochondria-Lysosome Live Cell Dye

Dual color (blue and red) small molecule probe for visualizing mitochondria-lysosome interactions during mitophagy.

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SCT244
1 mg  
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      Overview

      Replacement Information
      Description
      Catalogue NumberSCT244
      DescriptionBioTracker Dual-Color Mitochondria-Lysosome Live Cell Dye
      OverviewBackground
      The BioTracker™ Dual-Color Mitochondria-Lysosome Live Cell Dye (Coupa) is a fluorescent probe used to detect mitochondria-lysosome interactions (Chen, 2020).

      Mitochondrial-lysosomal interactions are fundamental to the processes of cellular homeostasis. Mitochondria and lysosomes have unique interactions which involve transfer of metabolites. Some disease pathogenesis can be linked to this important subcellular interaction (Chen, 2020). This BioTracker™ live cell probe is a unique cell-permeable and viscosity-responsive molecular probe that is capable of monitoring mitochondrial and lysosomal interactions in living cells. Through fluorescence conversion, this BioTracker™ dual color probe can simultaneously tag mitochondria with blue fluorescence and lysosomes with red fluorescence.

      Spectral Properties
      Fluorescence images obtained by λex = 405 nm and emission at 450 nm (Mitochondria) and λex = 561nm and emission at 590nm (Lysosome)

      Reference
      Chen, Qixin, et al. "A dual-labeling probe to track functional mitochondria–lysosome interactions in live cells." Nature Communications 11.1 (2020): 1-10.
      Alternate Names
      • Live Cell Imaging Probe
      References
      Product Information
      Detection methodFluorescence
      PresentationLyophilized. Brown solid.
      Quality LevelMQ100
      Applications
      ApplicationDual color (blue and red) small molecule probe for visualizing mitochondria-lysosome interactions during mitophagy.
      Key Applications
      • Cell Based Assays
      • Flow Cytometry
      • Fluorescence
      Application NotesLive cell fluorescent imaging
      Biological Information
      Molecular Weight586.46
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssurancePurity ≥ 98% confirmed by HPLC. Identification confirmed by HNMR, LC-MS, and elemental analysis.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -20°C, desiccated and protected from light.
      Note: Centrifuge vial briefly to collect contents at bottom of vial before opening
      Packaging Information
      Material Size1 mg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      SCT244 04065267689869