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196805 Bax Channel Blocker - CAS 335165-69-0 - Calbiochem

A cell-permeable dibromocarbazolo-piperazinyl derivative that displays anti-apoptotic properties.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (±)-1-(3,6-Dibromocarbazol-9-yl)-3-piperazin-1-yl-propan-2-ol, iMAC1

Primary Target: Bax-channel forming activity
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196805
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
335165-69-0C₁₉H₂₁Br₂N₃O

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196805-5MG
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      Description
      OverviewA cell-permeable dibromocarbazolo-piperazinyl derivative that displays anti-apoptotic properties. Effectively blocks Bid-induced cyctochrome c release from HeLa cell mitochondria (~80% inhibition at 5 µM) by inhibiting Bax channel-forming activity (IC50 = 520 nM in a liposome channel assay).
      Catalogue Number196805
      Brand Family Calbiochem®
      Synonyms(±)-1-(3,6-Dibromocarbazol-9-yl)-3-piperazin-1-yl-propan-2-ol, iMAC1
      References
      ReferencesPeixoto, P., et al. 2009. Biochem J. 423, 381.
      Bombrun, A., et al. 2003. J. Med. Chem. 46, 4365.
      Product Information
      CAS number335165-69-0
      ATP CompetitiveN
      FormOff-white solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₉H₂₁Br₂N₃O
      Chemical formulaC₁₉H₂₁Br₂N₃O
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetBax-channel forming activity
      Primary Target IC<sub>50</sub>520 nM blocks Bid-induced cyctochrome c release from HeLa cell mitochondria by inhibiting Bax channel-forming activity in a liposome channel assay
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      196805-5MG 04055977206524

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Bax Channel Blocker - CAS 335165-69-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Bax Channel Blocker - CAS 335165-69-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      196805

      References

      Reference overview
      Peixoto, P., et al. 2009. Biochem J. 423, 381.
      Bombrun, A., et al. 2003. J. Med. Chem. 46, 4365.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-July-2018 JSW
      Synonyms(±)-1-(3,6-Dibromocarbazol-9-yl)-3-piperazin-1-yl-propan-2-ol, iMAC1
      DescriptionA cell-permeable dibromocarbazole-piperazinyl derivative that displays anti-apoptotic properties. Reported to effectively block Bid-induced cytochrome c release from HeLa cell mitochondria (~80% inhibition at 5 µM) by inhibiting Bax channel activity.
      FormOff-white solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number335165-69-0
      Chemical formulaC₁₉H₂₁Br₂N₃O
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesPeixoto, P., et al. 2009. Biochem J. 423, 381.
      Bombrun, A., et al. 2003. J. Med. Chem. 46, 4365.