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203325 BMS - CAS 145626-87-5 - Calbiochem

Water-soluble reagent useful for the reduction of native disulfide bonds in proteins. Considered to be a superior reducing agent to DTT.

BMS - CAS 145626-87-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: bis(2-Mercaptoethylsulfone)

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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      145626-87-5C₄H₁₀O₂S₃
      Description
      OverviewWater-soluble reagent useful for the reduction of native disulfide bonds in proteins. Considered to be a superior reducing agent to DTT. Shown to reduce accessible disulfide bonds in immunoglobulin and trypsinogen under non-denaturing conditions 5 to 7 times faster than DTT at pH 7. The relatively less accessible disulfide bond in α-chymotrypsinogen A was reduced 2.3 times faster at with BMS than with DTT at pH 7.0.
      Catalogue Number203325
      Brand Family Calbiochem®
      Synonymsbis(2-Mercaptoethylsulfone)
      References
      ReferencesSingh, R., et al. 1995. Methods Enzymol. 251, 167.
      Singh, R., and Whitesides, G.M. 1994. Bioorg. Chem. 22, 109.
      Singh, R., and Whitesides, G.M. 1994. Protein Sci. 3, Suppl. 1, 430T.
      Lamoureux, G.V., and Whitesides, G.M. 1993. J. Org. Chem. 58, 633.
      Product Information
      CAS number145626-87-5
      FormWhite crystalline solid
      Hill FormulaC₄H₁₀O₂S₃
      Chemical formulaC₄H₁₀O₂S₃
      PKA7.9 and 9.0
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥99% by titration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      203325 0

      Documentation

      BMS - CAS 145626-87-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      BMS - CAS 145626-87-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      203325

      References

      Reference overview
      Singh, R., et al. 1995. Methods Enzymol. 251, 167.
      Singh, R., and Whitesides, G.M. 1994. Bioorg. Chem. 22, 109.
      Singh, R., and Whitesides, G.M. 1994. Protein Sci. 3, Suppl. 1, 430T.
      Lamoureux, G.V., and Whitesides, G.M. 1993. J. Org. Chem. 58, 633.

      Brochure

      Title
      Bulk Product Guide
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-April-2011 RFH
      Synonymsbis(2-Mercaptoethylsulfone)
      DescriptionWater-soluble reagent useful for the reduction of native disulfide bonds in proteins. Considered to be a superior reducing agent to DTT. Shown to reduce accessible disulfide bonds in immunoglobulin and trypsinogen under non-denaturing conditions 5 to 7 times faster than DTT at pH 7. The relatively less accessible disulfide bond in α-chymotrypsinogen A was reduced 2.3 times faster at pH 7 with BMS than with DTT. Has a pKa of 7.9 and 9.0.
      FormWhite crystalline solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number145626-87-5
      Chemical formulaC₄H₁₀O₂S₃
      Structure formulaStructure formula
      Purity≥99% by titration
      SolubilityDMSO, Ethanol, H₂O (1.8 mg/ml), or Methanol. May require warming (40-45°C) to achieve complete solubilization in H₂O.
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesSingh, R., et al. 1995. Methods Enzymol. 251, 167.
      Singh, R., and Whitesides, G.M. 1994. Bioorg. Chem. 22, 109.
      Singh, R., and Whitesides, G.M. 1994. Protein Sci. 3, Suppl. 1, 430T.
      Lamoureux, G.V., and Whitesides, G.M. 1993. J. Org. Chem. 58, 633.