506384 Sigma-AldrichBLM Helicase Inhibitor, ML216 - CAS 1430213-30-1 - Calbiochem
Recommended Products
Overview
| Replacement Information |
|---|
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 1430213-30-1 | C₁₅H₉F₄N₅OS |
Pricing & Availability
| Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
|---|---|---|---|---|---|---|
| 5.06384.0001 |
|
Glass bottle | 10 mg |
|
— |
| Description | |
|---|---|
| Overview | A cell-permeable pyridinyl-thiadiazolylurea compound that selectively blocks Bloom′s syndrome protein (BLM) helicase activity of both full-length as well as truncated BLM636-1298 forms (IC50 = 2.98 and 0.97 µM, respectively). Competes with and reversibly blocks DNA binding to BLM. However, the inhibition appears to be non-competitive with respect to ATP. Exhibits anti-proliferative activity in cells expressing BLM, but not in those lacking BLM. Induces sister chromatid exchanges (SCEs) and enhances the sensitivity of BLM containing PSNF5 cells to aphidicolin (Cat. No. 178273) without affecting PSNG13 cells that are devoid of BLM. Displays favorable microsomal (T1/2 > 1.2 h) and plasma stability (~100% at 5 h). |
| Catalogue Number | 506384 |
| Brand Family | Calbiochem® |
| Synonyms | 1-(4-Fluoro-3-(trifluoromethyl)phenyl)-3-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)urea, ML-216 |
| References | |
|---|---|
| References | Rosenthal, A.S., et al. 2013. Bioorg. Med. Chem. Lett. 23, 5660. Nguyen, G.H., et al. 2013. Chem. Biol. 20, 55. |
| Product Information | |
|---|---|
| CAS number | 1430213-30-1 |
| Form | Orange solid |
| Hill Formula | C₁₅H₉F₄N₅OS |
| Chemical formula | C₁₅H₉F₄N₅OS |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
|---|
| Biological Information | |
|---|---|
| Primary Target | BLM |
| Purity | ≥97% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Dimensions |
|---|
| Materials Information |
|---|
| Toxicological Information |
|---|
| Safety Information according to GHS |
|---|
| Safety Information |
|---|
| Product Usage Statements |
|---|
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
|---|
| Supplemental Information |
|---|
| Specifications |
|---|
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 5.06384.0001 | 04055977243284 |
Documentation
BLM Helicase Inhibitor, ML216 - CAS 1430213-30-1 - Calbiochem SDS
| Title |
|---|
References
| Reference overview |
|---|
| Rosenthal, A.S., et al. 2013. Bioorg. Med. Chem. Lett. 23, 5660. Nguyen, G.H., et al. 2013. Chem. Biol. 20, 55. |
| Data Sheet | ||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
|