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189400 Aurintricarboxylic Acid - CAS 4431-00-9 - Calbiochem

A cell-permeable polyanionic, polyaromatic compound used as a powerful inhibitor of cellular processes that are dependent on the formation of protein-nucleic acid complexes.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: ATA

Primary Target: DNA topoisomerase 2
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189400
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Overview

Key Spec Table

CAS #Empirical Formula
4431-00-9C₂₂H₁₄O₉

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189400-100MG
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      Description
      OverviewA cell-permeable polyanionic, polyaromatic compound used as a powerful inhibitor of cellular processes that are dependent on the formation of protein-nucleic acid complexes. Binds to aFGF and reduces its angiogenic activity. Shown to inhibit apoptotic cell death in various cell types induced by a variety of factors. ATA is a potent inhibitor of DNA topoisomerase II (IC50= 75 nM for the yeast enzyme as measured by relaxation assays) that also acts as a potent inhibitor of angiogenesis. Inhibits von Willebrand factor binding to platelets and reduces glutamate-induced neuronal injury. ATA stimulates the tyrosine phosphorylation of MAP kinases, Shc proteins, phosphatidylinositol 3-kinase, and phospholipase Cγ. Inhibits both major calpain isoforms (IC50 = 22 µM and IC50 = 10 µM for µ-calpain and m-calpain, respectively).
      Dye content: ~85%.
      Catalogue Number189400
      Brand Family Calbiochem®
      SynonymsATA
      References
      ReferencesLozano, R.M., et al. 1997. Eur. J. Biochem. 248, 30.
      Benchokroun, Y., et al. 1995. Biochem. Pharmacol. 49, 305.
      Okada, N., and Koizumi, S. 1995. J. Biol. Chem. 270, 16464.
      Posner, A., et al. 1995. Biochem. Mol. Biol. Int. 36, 291.
      Catchpoole, D.R., et al. 1994. Anticancer Res. 14, 853.
      Csernansky, C.A., et al. 1994. J. Neurosci. Res. 38, 101.
      Gagliardi, A.R., and Collins, D.C. 1994. Anticancer Res. 14, 475.
      Gonzalez, R.G., et al. 1980. Biochemistry 19, 4299.
      Product Information
      CAS number4431-00-9
      ATP CompetitiveN
      FormRed solid
      Hill FormulaC₂₂H₁₄O₉
      Chemical formulaC₂₂H₁₄O₉
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetDNA topoisomerase 2
      Primary Target IC<sub>50</sub>75 nM against DNA topoisomerase II
      Purity≥85% by Titration
      Physicochemical Information
      Cell permeableY
      Safety Information according to GHS
      RTECSGU4790000
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      189400-100MG 04055977221725