Millipore Sigma Vibrant Logo

616371 Aprotinin, Bovine, Recombinant, Nicotiana sp., Animal-Free - CAS 9087-70-1 - Calbiochem

Aprotinin, Bovine, Recombinant, Nicotiana sp, Animal-Free - CAS 9087-70-1, is a heat and acid-stable competitive, reversible inhibitor of serine proteases.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Pancreatic Trypsin Inhibitor, Trypsin-Kallikrein Inhibitor, Kallikrein-Trypsin Inactivator, Antikrein, Basic Pancreatic Trypsin Inhibitor

Primary Target: chymotrypsin
View Products on Sigmaaldrich.com
616371
View Pricing & Availability

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
9087-70-1C₂₈₄H₄₃₂N₈₄O₇₉S₇

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
616371-1MG
Retrieving availability...
—
Limited Availability Limited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      		 Plastic ampoule 1 mg
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      —
      Request Pricing
      		 —
      616371-25MG
      Retrieving availability...
      —
      Limited Availability Limited Availability
      In Stock 
      Discontinued
      Limited Quantities Available
      Availability to be confirmed
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          		 Glass bottle 25 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity is a multiple of
          Maximum Quantity is
          Upon Order Completion More Information
          You Saved ()
           
          —
          Request Pricing
          		 —
          616371-5MG
          Retrieving availability...
          —
          Limited Availability Limited Availability
          In Stock 
          Discontinued
          Limited Quantities Available
          Availability to be confirmed
            Remaining : Will advise
              Remaining : Will advise
              Will advise
              Contact Customer Service
              Contact Customer Service

              		 Plastic ampoule 5 mg
              Retrieving price...
              Price could not be retrieved
              Minimum Quantity is a multiple of
              Maximum Quantity is
              Upon Order Completion More Information
              You Saved ()
               
              —
              Request Pricing
              		 —
              Description
              OverviewRecombinant, bovine aprotinin supplied without animal-derived components. Aprotinin is a competitive, reversible inhibitor of proteolytic and esterolytic activity. A relatively heat- and acid-stable serine protease inhibitor. Forms a tight complex, blocking the active site of the enzyme. Effective at concentrations equimolar with protease. Inhibits several proteases, including coagulation factors in the prephase of blood clotting, tissue and leukocytic proteinases, chymotrypsin, trypsin (Kd = 5 x 10-14 M), plasmin (Kd = 2.3 x 10-10 M), and kallikrein (Kd = 1 x 10-7 M). Proteases not inhibited by aprotinin include Factor Xa, thrombin, pepsin, papain, and carboxypeptidases A and B. Useful for protein purification and for extending the life of cells in culture by preventing proteolytic damage.
              Catalogue Number616371
              Brand Family Calbiochem®
              SynonymsPancreatic Trypsin Inhibitor, Trypsin-Kallikrein Inhibitor, Kallikrein-Trypsin Inactivator, Antikrein, Basic Pancreatic Trypsin Inhibitor
              References
              ReferencesDeutscher, M.P., 1990. Methods Enzymol. 182, 83.
              Product Information
              CAS number9087-70-1
              Unit of DefinitionOne TIU (Trypsin Inhibitory Unit) will decrease the activity of two trypsin units by 50% where one trypsin unit will hydrolyze 1.0 µmole of Nα-benzoyl-L-Arginine-p-Nitroanilide (L-BAPNA) per minute at pH 7.8 at 25°C.
              ATP CompetitiveN
              EC number2329949
              FormWhite to off-white powder
              FormulationContains no animal-derived components.
              Hill FormulaC₂₈₄H₄₃₂N₈₄O₇₉S₇
              Chemical formulaC₂₈₄H₄₃₂N₈₄O₇₉S₇
              ReversibleY
              Quality LevelMQ200
              Applications
              Biological Information
              Primary Targetchymotrypsin
              Primary Target IC<sub>50</sub>Kd = 5 x 10-14 M, 2.3 x 10-10 M, 1 x 10-7 M against trypsin, plasmin, and kallikrein, respectively
              Purity≥98% by SDS-PAGE
              Specific Activity≥5.0 EPU/mg protein
              Concentration Label Please refer to vial label for lot-specific concentration
              Physicochemical Information
              Cell permeableN
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              RTECSYN5080000
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Blue Ice Only
              Toxicity Standard Handling
              Storage +2°C to +8°C
              Do not freeze Ok to freeze
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications
              Global Trade Item Number
              Catalogue Number GTIN
              616371-1MG 04055977262919
              616371-25MG 04055977262926
              616371-5MG 04055977262933

              Documentation

              Aprotinin, Bovine, Recombinant, Nicotiana sp., Animal-Free - CAS 9087-70-1 - Calbiochem SDS

              Title

              Safety Data Sheet (SDS) 

              Aprotinin, Bovine, Recombinant, Nicotiana sp., Animal-Free - CAS 9087-70-1 - Calbiochem Certificates of Analysis

              TitleLot Number
              616371

              References

              Reference overview
              Deutscher, M.P., 1990. Methods Enzymol. 182, 83.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision08-August-2024 JSW
              SynonymsPancreatic Trypsin Inhibitor, Trypsin-Kallikrein Inhibitor, Kallikrein-Trypsin Inactivator, Antikrein, Basic Pancreatic Trypsin Inhibitor
              DescriptionRecombinant, bovine aprotinin supplied without animal-derived components. Aprotinin is a competitive, reversible inhibitor of proteolytic and esterolytic activity. A relatively heat- and acid-stable serine protease inhibitor. Forms a tight complex, blocking the active site of the enzyme. Effective at concentrations equimolar with protease. Inhibits several proteases, including coagulation factors in the prephase of blood clotting, tissue and leukocytic proteinases, chymotrypsin, trypsin (Kd = 5 x 10-14 M), plasmin (Kd = 2.3 x 10-10 M), and kallikrein (Kd = 1 x 10-7 M). Proteases not inhibited by aprotinin include Factor Xa, thrombin, pepsin, papain, and carboxypeptidases A and B. Useful for protein purification and for extending the life of cells in culture by preventing proteolytic damage.
              FormWhite to off-white powder
              FormulationContains no animal-derived components.
              Concentration Label Please refer to vial label for lot-specific concentration
              CAS number9087-70-1
              RTECSYN5080000
              EC number2329949
              Chemical formulaC₂₈₄H₄₃₂N₈₄O₇₉S₇
              Purity≥98% by SDS-PAGE
              Specific activity≥5.0 EPU/mg protein
              Unit definitionOne TIU (Trypsin Inhibitory Unit) will decrease the activity of two trypsin units by 50% where one trypsin unit will hydrolyze 1.0 µmole of Nα-benzoyl-L-Arginine-p-Nitroanilide (L-BAPNA) per minute at pH 7.8 at 25°C.
              Storage +2°C to +8°C
              Do Not Freeze Ok to freeze
              Toxicity Standard Handling
              Merck USA index14, 757
              ReferencesDeutscher, M.P., 1990. Methods Enzymol. 182, 83.