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ABN161-I Anti-pan Neurexin-1 Antibody

Anti-pan Neurexin-1 Antibody detects level of pan Neurexin-1 and has been published and validated for use in Western Blotting, Immunohistochemistry (Paraffin).

Anti-pan Neurexin-1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: Nrxn1, Kiaa0578 UniProt Number: Q9CS84
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ABN161-I
100 μg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, R, HWB, IH(P)RbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABN161-I
      ReplacesABN161
      DescriptionAnti-pan Neurexin-1 Antibody
      Alternate Names
      • Neurexin-1
      • Neurexin-1-alpha
      • Neurexin I-alpha
      Background InformationNeurexin-1 (UniProt Q9CS84; also known as Neurexin I-alpha, Neurexin-1-alpha) is encoded by the Nrxn1 (also known as Kiaa0578) gene (Gene ID 18189) in murine species. Neurexin (NRXN) is a presynaptic single pass transmembrane protein that assists in joining neurons together at the synapse. Neurexins mediate signaling across the synapse and neural networks by specifying synpatic function. Mutations in the genes encoding for neurexins are implicated in autism, schizphrenia, and nicotine dependence. There are two classifications of neurexins, α-NRXNs and β-NRXNs. The α-NRXNs are larger and have different amino-terminal extracellular sequences than β-NRXNs. β-NRXNs act as receptors for neuroligin and have been found to play a role in angiogenesis.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-pan Neurexin-1 Antibody detects level of pan Neurexin-1 and has been published and validated for use in Western Blotting, Immunohistochemistry (Paraffin).
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Neurexin-1 in mouse, rat, and human cerebral cortex tissue sections.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to a cytoplasmic domain sequence near the C-teminus of mouse neurexin-1.
      EpitopeNear C-terminus.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityExpected to react with all neurexin-1-alpha and neurexin-1-beta spliced isoforms of murine, human, and rat species, as this polyclonal antibody targets the C-terminal end cytoplasmic sequence that is not affected by alternative splicings (Missler, M., and Südhof, T.C. (1998). Trends Genet. 14(1):20-26). Cross-reactivities toward alpha and beta isoforms of neurexin-2 and neurexin-3 are also likely, although the C-termminal sequence is not 100% conserved among neurexin-1, neurexin-2 and neurexin-3.
      Species Reactivity
      • Mouse
      • Rat
      • Human
      Species Reactivity NoteMouse, Rat, Human. Predicted to react with Bovine based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Nrxn1
      • Kiaa0578
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~170/55/40 kDa observed. Varible depending on the isoform(s) present in the test sample(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse brain tissue lysate.

      Western Blotting Analysis: 0.2 µg/mL of this antibody detected Neurexin-1 in 10 µg of mouse brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABN161-I 04055977314199

      Documentation

      Anti-pan Neurexin-1 Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-pan Neurexin-1 Antibody Certificates of Analysis

      TitleLot Number
      Anti-pan Neurexin-1 - 3212323 3212323
      Anti-pan Neurexin-1 - 3218767 3218767
      Anti-pan Neurexin-1 - 3251458 3251458
      Anti-pan Neurexin-1 - 3305870 3305870
      Anti-pan Neurexin-1 - 3457054 3457054
      Anti-pan Neurexin-1 - 4097737 4097737
      Anti-pan Neurexin-1 - 4197958 4197958
      Anti-pan Neurexin-1 - 4209983 4209983
      Anti-pan Neurexin-1 -2819305 2819305
      Anti-pan Neurexin-1 -Q2640658 Q2640658
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      Brochure

      Title
      Neuroscience Solutions for productive research