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MABN254 Anti-amyloid beta peptide (MOAB-2), pan Antibody, clone 6C3

Anti-amyloid beta peptide (MOAB-2), pan Antibody, clone 6C3 is an antibody against amyloid beta peptide (MOAB-2), pan, clone 6C3 for use in western blotting, IHC (Paraffin), Immunofluorescence, IP, Dot Blot.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurodegenerative Diseases Gene Symbol: APP, A4, AD1 UniProt Number: P05067
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MABN254
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IH(P), IF, IP, DBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN254
      DescriptionAnti-amyloid beta peptide (MOAB-2), pan Antibody, clone 6C3
      Alternate Names
      • Amyloid beta A4 protein
      • ABPP
      • APPI
      • APP
      • Alzheimer's disease amyloid protein
      • cerebral vascular amyloid peptide
      • CVAP
      • PreA4
      • Protease nexin-II
      • PN-II
      Background InformationPan-amyloid-beta (1-40) is one of several functional peptides (39 to 43 amino acids in length) formed from proteolytic cleavage of the amyloid-beta precursor protein (APP) by the family of secretase enzymes. Although the APP protein is required for a number of biological functions, including axonal transport, cell adhesion, and transcription, the Ab 1-40 peptide has been studied mostly for its potential to aggregate and form neurite plaques, which may contribute to neurotoxicity, particularly in the context of neurodegenerative disease such as Alzheimer’s. Previous studies have demonstrated that Anti-pan amyloid beta peptide (MOAB2), clone 6C3 detects specifically amyloid-beta, but not APP. Furthermore MOAB2 detects multiple amyloid-beta 40 and amyloid-beta 42 conformations including unaggregated, oligomeric and fibrillar. In a number of immunohistochemical and biochemical analyses, MOAB2 consistently detected intraneuronal amyloid-beta, but not APP, and showed greater specificity to amyloid-beta than 6E10. MOAB2 is therefore suitable for sensitive and specific detection of accumulating amyloid-beta peptides in Alzheimer’s disease models.
      References
      Product Information
      FormatPurified
      Control
      • Alzheimer's diseased human brain tissue.
      PresentationPurified mouse monoclonal IgG2aλ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-amyloid beta peptide (MOAB-2), pan Antibody, clone 6C3 is an antibody against amyloid beta peptide (MOAB-2), pan, clone 6C3 for use in western blotting, IHC (Paraffin), Immunofluorescence, IP, Dot Blot.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      • Immunofluorescence
      • Immunoprecipitation
      • Dot Blot
      Application NotesImmunofluorescence Analysis: A 1:1,000 dilution from a representative lot detected Amyloid Beta Peptide in human Alzeimer's diseased brain (see website for images).

      Western Blot Analysis: A representative lot was used by an independent laboratory in unaggregated forms of Aß42 and Aß40. (Youmans, K.L., et al. (2012). Mol Neurodegener. 7;8.)

      Dot Blot Analysis: Serial Aβ40 and Aβ42 dilutions were probed with MOAB-2 or 6E10 by an independent laboratory. (Youmans, K.L., et al. (2012). Mol Neurodegener. 7;8.)

      Immunoprecipitationt Analysis: A representative lot was used by an independent laboratory in unaggregated and fibrillar forms of Aß42 and Aß40. (Youmans, K.L., et al. (2012). Mol Neurodegener. 7;8.)
      Biological Information
      ImmunogenLinear peptide corresponding to human pan amyloid beta peptide (MOAB-2).
      Clone6C3
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThis antibody recognizes amyloid-ß and not APP (amyloid precursor protein). Specifically, clone 6C3 recognizes unaggregated, oligomeric, and fibrillar forms of Aß42 and Aß40.
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • APP
      • A4
      • AD1
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight4 kDa calculated but could be larger since clone 6C3 recognizes unaggregated, oligomeric, and fibrillar forms of Aß42 and Aß40.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in Alzheimer's diseased human brain tissue.

      Immunohistochemistry Analysis: A 1:1,000 dilution of this antibody detected Amyloid Beta Peptide in human Alzheimer's diseased brain tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABN254 04053252698507

      Documentation

      Anti-amyloid beta peptide (MOAB-2), pan Antibody, clone 6C3 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-amyloid beta peptide (MOAB-2), pan Antibody, clone 6C3 Certificates of Analysis

      TitleLot Number
      Anti-amyloid beta peptide (MOAB-2), -2613128 2613128
      Anti-amyloid beta peptide (MOAB-2), -2660168 2660168
      Anti-amyloid beta peptide (MOAB-2), -2793610 2793610
      Anti-amyloid beta peptide (MOAB-2), pan, clone 6C3 - 2430547 2430547
      Anti-amyloid beta peptide (MOAB-2), pan, clone 6C3 - 2219403 2219403
      Anti-amyloid beta peptide (MOAB-2), pan, clone 6C3 - 2298456 2298456
      Anti-amyloid beta peptide (MOAB-2), pan, clone 6C3 - 3246198 3246198
      Anti-amyloid beta peptide (MOAB-2), pan, clone 6C3 - 3434650 3434650
      Anti-amyloid beta peptide (MOAB-2), pan, clone 6C3 - 3609982 3609982
      Anti-amyloid beta peptide (MOAB-2), pan, clone 6C3 - 3713390 3713390
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      References

      Reference overviewPub Med ID
      Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody.
      Youmans, Katherine L, et al.
      Mol Neurodegener, 7: 8 (2012)  2012

      Show Abstract       		22423893 22423893

      Newsletters / Publications

      Title
      Research Focus - Volume 2, 2013

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies