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PC37 Anti-VEGF (Ab-2) Rabbit pAb

Anti-VEGF (Ab-2) Rabbit pAb MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Anti-Vascular Endothelial Growth Factor, Anti-Vascular Permeability Factor, Anti-VPF

PC37
  
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      Overview

      Replacement Information

      Key Spec Table

      Host
      Rb
      Description
      Overview

      This product has been discontinued.





      Recognizes the ~46 kDa (dimer) VEGF protein in fetal tissue.
      Catalogue NumberPC37
      Brand Family Calbiochem®
      SynonymsAnti-Vascular Endothelial Growth Factor, Anti-Vascular Permeability Factor, Anti-VPF
      References
      ReferencesKlagsbrun, M., and Soker, S., 1993. Current Biology 3, 699.
      Senger, D., et al. 1993. Cancer Metastasis Rev. 12, 303.
      Brown, L., et al. 1992. Kidney International 42, 1457.
      Dvorak, H., et al. 1991. Exp. Med. 174, 1275.
      Product Information
      FormLiquid
      FormulationIn 0.05 M sodium phosphate buffer, 0.2% gelatin.
      Positive controlRecombinant VEGF protein
      Preservative≤0.1% sodium azide
      Applications
      Application ReferencesParaffin Sections Klein, M., et al. 1999. J. Endrocrin. 161 41. Mouse Cross-Reactivity Villegas, G., et al. 2005. Kidney International 67, 449.
      Key Applications Immunoblotting (Western Blotting)
      Paraffin Sections
      Application NotesImmunoblotting (2.5 µg/ml)
      Paraffin sections (5 µg/ml, trypsin pre-treatment required, see application references)
      Application CommentsAntibody should be titrated for optimal results in individual systems.
      Biological Information
      Immunogena synthetic peptide corresponding to amino acids at the extreme N-terminus of human VEGF₁₆₅
      ImmunogenHuman
      HostRabbit
      IsotypeIgG
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Yes
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      PC37 0

      Documentation

      Anti-VEGF (Ab-2) Rabbit pAb SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-VEGF (Ab-2) Rabbit pAb Certificates of Analysis

      TitleLot Number
      PC37

      References

      Reference overview
      Klagsbrun, M., and Soker, S., 1993. Current Biology 3, 699.
      Senger, D., et al. 1993. Cancer Metastasis Rev. 12, 303.
      Brown, L., et al. 1992. Kidney International 42, 1457.
      Dvorak, H., et al. 1991. Exp. Med. 174, 1275.

      Citations

      Title
    • Guillermo Villegas, Baerbel Lange-Sperandio and Alda Tufro. (2005) Autocrine and Paracrine Functions of Vascular Endothelial Growth Factor (VEGF) in Renal Tubular Epithelial Cells. Kidney International 67, 449-457.
    • M. Klein, et al. (1999) Vascular endothelial growth factor gene and protein: strong expression in thyroiditis and thyroid carcinoma. Journal of Endocrinology 161, 41-49.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-October-2007 RFH
      SynonymsAnti-Vascular Endothelial Growth Factor, Anti-Vascular Permeability Factor, Anti-VPF
      ApplicationImmunoblotting (2.5 µg/ml)
      Paraffin sections (5 µg/ml, trypsin pre-treatment required, see application references)
      DescriptionPurified rabbit polyclonal antibody. Recognizes the VEGF121, VEGF165, VEGF189, and VEGF206 forms of VEGF.
      BackgroundVascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF), is a secreted heparin binding cytokine expressed in tumor and animal cells. It has been implicated in the control of angiogenesis due to its selective mitogenic stimulation of vascular endothelial cells and enhancement of vascular permeability. Other effects of VEGF on vascular endothelial cells include; increasing intracellular calcium, stimulating inositol triphosphate formation, induction of von Willebrand factor release, and stimulating tissue factor expression. VEGF is a ~46 kDa dimer of two identical disulfide-linked subunits existing in four molecular species; 121, 165, 189, and 206 amino acid residues long.
      HostRabbit
      Immunogen speciesHuman
      Immunogena synthetic peptide corresponding to amino acids at the extreme N-terminus of human VEGF₁₆₅
      IsotypeIgG
      Specieshuman, mouse
      Positive controlRecombinant VEGF protein
      FormLiquid
      FormulationIn 0.05 M sodium phosphate buffer, 0.2% gelatin.
      Concentration Label Please refer to vial label for lot-specific concentration
      Preservative≤0.1% sodium azide
      CommentsAntibody should be titrated for optimal results in individual systems.
      Storage +2°C to +8°C
      Do Not Freeze Yes
      Toxicity Standard Handling
      ReferencesKlagsbrun, M., and Soker, S., 1993. Current Biology 3, 699.
      Senger, D., et al. 1993. Cancer Metastasis Rev. 12, 303.
      Brown, L., et al. 1992. Kidney International 42, 1457.
      Dvorak, H., et al. 1991. Exp. Med. 174, 1275.
      Citation
    • Guillermo Villegas, Baerbel Lange-Sperandio and Alda Tufro. (2005) Autocrine and Paracrine Functions of Vascular Endothelial Growth Factor (VEGF) in Renal Tubular Epithelial Cells. Kidney International 67, 449-457.
    • M. Klein, et al. (1999) Vascular endothelial growth factor gene and protein: strong expression in thyroiditis and thyroid carcinoma. Journal of Endocrinology 161, 41-49.
      		•
      Application referencesParaffin Sections Klein, M., et al. 1999. J. Endrocrin. 161 41. Mouse Cross-Reactivity Villegas, G., et al. 2005. Kidney International 67, 449.

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies