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MABE152 Anti-SRp55 Antibody, clone 9-1-56

Use Anti-SRp55 Antibody, clone 9-1-56 (Mouse Monoclonal Antibody) validated in WB, IP, ICC, IHC to detect SRp55 also known as arginine/serine-rich splicing factor 6, Pre-mRNA-splicing factor SRP55.

Anti-SRp55 Antibody, clone 9-1-56 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: RNA Metabolism & Binding Proteins Gene Symbol: SRP55, SFRS6, B52 UniProt Number: Q13247
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MABE152
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IP, ICC, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABE152
      DescriptionAnti-SRp55 Antibody, clone 9-1-56
      Alternate Names
      • splicing factor, arginine/serine-rich 6
      • arginine/serine-rich splicing factor 6
      • splicing factor, arginine/serine-rich, 55 kDa
      • Pre-mRNA-splicing factor SRP55
      • pre-mRNA splicing factor SRP55
      Background InformationPre-mRNA-splicing factor SRp55 is a member of the serine/arginine-rich (SR) protein family. This group of proteins is found mainly in the nucleus where they play a critical role in regulated and constitutive splicing of precursor mRNAs. SRp55 is involved in the constitutive process for mRNA splicing, and is able to mediate alternative splice site selection. Considered one of the more ubiquitous of the splice factors, SRp55 is upregulated in response to DNA damage when p53 is lacking. SRp55 is significantly phosphorylated on RS domain serine residues.
      References
      Product Information
      FormatPurified
      Control
      • HeLa cell lysate
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl without 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationUse Anti-SRp55 Antibody, clone 9-1-56 (Mouse Monoclonal Antibody) validated in WB, IP, ICC, IHC to detect SRp55 also known as arginine/serine-rich splicing factor 6, Pre-mRNA-splicing factor SRP55.
      Key Applications
      • Western Blotting
      • Immunoprecipitation
      • Immunocytochemistry
      • Immunohistochemistry
      Biological Information
      ImmunogenMBP-tagged recombinant protein corresponding to human SRp55.
      EpitopeNot determined
      Clone9-1-56
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is involved in mRNA splicing and may play a role in the determination of alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12. Alternative splicing results in multiple transcript variants.
      Gene Symbol
      • SRP55
      • SFRS6
      • B52
      Purification MethodProtein G
      UniProt Number
      UniProt SummaryFUNCTION: Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.

      SUBUNIT STRUCTURE: Binds SFRS12.

      SUBCELLULAR LOCATION: Nucleus.

      PTM: Extensively phosphorylated on serine residues in the RS domain (By similarity).

      SEQUENCE SIMILARITIES: Belongs to the splicing factor SR family.

      Contains 2 RRM (RNA recognition motif) domains.
      Molecular Weight ~ 43 kDa observed. 40 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in HeLa cell lysate.

      Western Blot Analysis: 0.5 µg/mL of this antibody detected SRp55 on 10 µg of HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABE152 04053252246388

      Documentation

      Anti-SRp55 Antibody, clone 9-1-56 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-SRp55 Antibody, clone 9-1-56 Certificates of Analysis

      TitleLot Number
      Anti-SRp55, clone 9-1-56 - 2019800 2019800
      Anti-SRp55, clone 9-1-56 - 2204957 2204957
      Anti-SRp55, clone 9-1-56 - 3854162 3854162
      Anti-SRp55, clone 9-1-56 - 3990655 3990655
      Anti-SRp55, clone 9-1-56 - NG1946570 NG1946570
      Anti-SRp55, clone 9-1-56 - NRG1773118 NRG1773118
      Anti-SRp55, clone 9-1-56 -2504896 2504896
      Anti-SRp55, clone 9-1-56 -2759701 2759701
      Anti-SRp55, clone 9-1-56 Monoclonal Antibody 3084180

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies