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ABN494 Anti-PHOX2A Antibody

Anti-PHOX2A Antibody is a highly specific rabbit polyclonal antibody, that targets Phox2a & has been tested in western blotting & IHC.

Anti-PHOX2A Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurodegenerative Diseases Gene Symbol: PMX2A, NCAM2, FEOM2, CFEOM2, ARIX, PHO2A UniProt Number: O14813
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ABN494
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RWB, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABN494
      DescriptionAnti-PHOX2A Antibody
      Alternate Names
      • Paired-like homeobox 2A
      • Paired mesoderm homeobox protein 2A
      Background InformationPaired mesoderm homeobox protein 2A (PHOX2A), also known as ARIX1 homeodomain protein (ARIX) and Paired-like homeobox 2A (PMX2A), along with the closely related PHOX2B, is a paired-homeodomain transcription factor that maintains the noradrenergic phenotype during embryogenesis. PHOX2 proteins help regulate endogenous hydroxylases in neural crest cells and aid in sympathetic neuron generation. PHOX2A controls only the differentiation of the main noradrenergic center of the human brain, while PHOX2B is required for the differentiation of all central and nonperipheral noradrenergic centers. PHOX2A may be involved in regulating specific expression of catecholamine biosynthetic genes. PHOX2A is linked to congenital fibrosis of extraocular muscles type 2 (CFEOM2). PHOX2 regulation may have therapeutic applications for aging or degenerative noradrenergic neuron disorders.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Rat brain tissue lysate
      PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-PHOX2A Antibody is a highly specific rabbit polyclonal antibody, that targets Phox2a & has been tested in western blotting & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: 2.5 µg/mL from a representative lot detected PHOX2A in human brain tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human PHOX2A.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      • Rat
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • PMX2A
      • NCAM2
      • FEOM2
      • CFEOM2
      • ARIX
      • PHO2A
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~32 kDa observed. Uncharacterized bands may appear in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting/Peptide Inhibition Assay in rat brain tissue lysate.

      Western Blotting/Peptide Inhibition Assay Analysis: 1µg/mL of this antibody detected PHOX2A in 15 µg of rat brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABN494 04053252907029