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MABS519-AF488 Anti-P40 Antibody, clone 11F12.1, Alexa Fluor® 488

This Alexa Fluor® 488 conjugated Anti-P40 Antibody, clone 11F12.1, is validated for use in Immunocytochemistry (IHC) for the detection of P-40.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Signaling Neuroscience Gene Symbol: TP63, KET, P63, P73H, P73L, TP73L UniProt Number: Q9H3D4

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MABS519-AF488
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MICCMAlexaFluor®488Monoclonal Antibody
      Description
      Catalogue NumberMABS519-AF488
      DescriptionAnti-P40 Antibody, clone 11F12.1, Alexa Fluor® 488
      Alternate Names
      • Tumor protein 63
      • p63
      • Chronic ulcerative stomatitis protein
      • CUSP
      • Keratinocyte transcription factor KET
      • Transformation-related protein 63
      • TP63
      • Tumor protein p73-like
      • p73L
      • p40
      • p51
      • P40
      Background InformationTumor protein 63 (UniProt Q9H3D4; also known as Amplified in squamous cell carcinoma, Chronic ulcerative stomatitis protein, CUSP, Keratinocyte transcription factor KET, p40, p51, p73L, TP63, Transformation-related protein 63, Tumor protein p73-like) is encoded by the TP63 (also known as KET, P63, P73H, P73L, TP73L) gene (Gene ID 8626) in human. Tumor protein 63 is a p53 homologue that can bind p53-responsive elements to upregulate some p53 target genes and share partially overlapping functions with p53. Various functions have been ascribed to TP63 in normal squamous epithelia, including those of the esophagus and TP63 is reported to play an essential role in the maintenance of proliferative potential in epithelial stem cells. TP63 overexpression is found in various squamous epithelia carcinomas and high TP63 expression is associated with an aggressive phenotype and metastasis in many cancers.
      References
      Product Information
      FormatAlexaFluor®488
      PresentationPurified mouse conjugate antibody in PBS with 15 mg/ml BSA and 0.1 sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Alexa Fluor® 488 conjugated Anti-P40 Antibody, clone 11F12.1, is validated for use in Immunocytochemistry (IHC) for the detection of P-40.
      Key Applications
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: A 1:100 dilution from a representative lot detected P40 in HUVEC cells.
      The unconjugated version (Cat. No. MABS519) has been shown to work in WB, IH(P).
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human P40 near the N-terminus.
      EpitopeNear N-terminus
      Clone11F12.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityExpected to react with spliced isoform 2 (DeltaN-alpha, DeltaNp63 alpha, P51delNalpha), 4 (DeltaN-beta, DeltaNp63 beta, P51delNbeta), 6 (DeltaN-gamma, DeltaNp63gamma, P51delNgamma), 8 (DeltaN-delta), 10 (DeltaN-epsilon, DeltaNp73L), 12, but not isoform 1 (TA*-alpha, TAp63alpha, P51B), 3 (TA*-beta, TAp63beta), 5 (TA*-gamma, TAp63gamma, P51A), 7 (TA*-delta, TAp63delta, P51delta), 9 (TA*-epsilon), or 11 (P63 delta).
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TP63
      • KET
      • P63
      • P73H
      • P73L
      • TP73L
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~40 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunocytochemistry in NIH/3T3 cells.

      Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected P40 in NIH/3T3 cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABS519-AF488 04055977275230

      Documentation

      Anti-P40 Antibody, clone 11F12.1, Alexa Fluor® 488 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-P40 Antibody, clone 11F12.1, Alexa Fluor® 488 Certificates of Analysis

      TitleLot Number
      Anti-P40, clone 11F12.1, Alexa Fluor® 488 - 3239826 3239826
      Anti-P40, clone 11F12.1, Alexa Fluor® 488 - 3393300 3393300
      Anti-P40, clone 11F12.1, Alexa Fluor® 488 - 3866798 3866798
      Anti-P40, clone 11F12.1, Alexa Fluor® 488 -Q2592812 Q2592812
      Anti-P40, clone 11F12.1, Alexa Fluor®488 2940927

      Brochure

      Title
      New Products Flyer- Vol 4 Signaling Feature- NEW! Phosphohistidine Antibody

      Technical Info

      Title
      Characterization of Estrogen Receptor α Phosphorylation Sites in Breast Cancer Tissue Using the SNAP i.d® 2.0 System
      White Paper: Further considerations of antibody validation and usage.

      Posters

      Title
      Post-Translational Modifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies