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MAB5620 Anti-Norepinephrine Transporter Antibody

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MAB5620
100 µL  
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      Overview

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MkIHCMAscitesMonoclonal Antibody
      Description
      Catalogue NumberMAB5620
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Norepinephrine Transporter Antibody
      Alternate Names
      • NET
      Product Information
      FormatAscites
      PresentationMouse ascites. Liquid. Contains no preservative.
      Quality LevelMQ100
      Applications
      ApplicationDetect Norepinephrine Transporter using this Anti-Norepinephrine Transporter Antibody validated for use in IH.
      Key Applications
      • Immunohistochemistry
      Biological Information
      ImmunogenSynthetic peptide from human norepinephrine Transporter.
      HostMouse
      SpecificityNorepinephrine Transporter, human and non-human primate.
      IsotypeIgG
      Species Reactivity
      • Human
      • Monkey
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe SLC6A2 gene encodes a norepinephrine (noradrenaline) transporter, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis (Kim et al., 2006 [PubMed 17146058]).[supplied by OMIM]
      Gene Symbol
      • SLC6A2
      • NET
      • SLC6A5
      • NAT1
      • NET1
      Purification MethodAscites
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P23975 # Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.
      SIZE: 617 amino acids; 69332 Da
      SUBUNIT: Interacts with PRKCABP.
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
      DISEASE: SwissProt: P23975 # Defects in SLC6A2 are a cause of orthostatic intolerance (OI) [MIM:604715]. OI is a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. It is associated with postural tachycardia. Plasma norepinephrine concentration is abnormally high.
      SIMILARITY: SwissProt: P23975 ## Belongs to the sodium:neurotransmitter symporter (SNF) family.
      MISCELLANEOUS: This protein is the target of psychomotor stimulants such as amphetamines or cocaine.
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µL
      Global Trade Item Number
      Catalogue Number GTIN
      MAB5620 04053252506086