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MABF2202-25UG Anti-MOSPD2 Antibody, clone 1MOS‐4E10

Anti-MOSPD2, clone 1MOS‐4E10, Cat. No. MABF2202, is a mouse monoclonal antibody that detects Motile sperm domain-containing protein 2 and is tested for use in Immunohistochemistry and Western Blotting.

MABF2202-25UG
25 μg  
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      Overview

      Replacement Information
      Description
      Catalogue NumberMABF2202-25UG
      DescriptionAnti-MOSPD2 Antibody, clone 1MOS‐4E10
      Alternate Names
      • Motile sperm domain-containing protein 2
      Background InformationMotile sperm domain-containing protein 2 (UniProt: Q8NHP6; also known as MOSPD2 is encoded by the MOSPD2 gene (Gene ID: 158747) in human. MOSPD2 is a single-pass FFAT-motif (two phenylalanines (FF) in an acidic track (AT)) interacting membrane protein. It binds to FFAT motif via its major sperm protein (MSP) domain (aa 327-445). MOSPD2 is an endoplasmic reticulum (ER)-anchored protein that interacts with several FFAT-containing tether proteins from endosomes, mitochondria, and Golgi and mediate the formation of contact sites between the ER and these organelles. MOSPD2 is highly expressed in CD14+ monocytes and at lower levels in neutrophils. Its expression is not observed in B- and T- cells. It is reported to promote migration of primary monocytes and neutrophils, in response to various chemokines. It consists of three structural domains: an N-terminal CRAL/TRIO domain that is involved in small lipophilic molecule binding, a MSP domain, and a carboxyl terminal transmembrane domain. Two isoforms of MOSPD2 have been described that are produced by alternative splicing. (Ref.: Di Mattia, T., et al. (2018). EMBO Rep.19(7): e45453).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-MOSPD2, clone 1MOS‐4E10, Cat. No. MABF2202, is a mouse monoclonal antibody that detects Motile sperm domain-containing protein 2 and is tested for use in Immunohistochemistry and Western Blotting.
      Key Applications
      • Immunohistochemistry
      • Western Blotting
      Application NotesWestern Blotting Analysis: 2 µg/mL from a representative lot detected MOSPD2 in Panc-1 cell lysate.

      Western Blotting Analysis: A representative lot detected MOSPD2 in Western Blotting applications (Di Mattia, T., et. al. (2018). EMBO Rep. 19(7); e45453).

      Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user.
      Biological Information
      ImmunogenA recombinant fragment corresponding to 119 amino acid MSP domain of human Motile sperm domain-containing protein 2 (MOSPD2).
      Clone1MOS‐4E10
      Concentration1 mg/mL. Please refer to guidance on suggested starting dilutions and/or titers per application and sample type.
      HostMouse
      SpecificityClone 1MOS‐4E10 is a mouse monoclonal antibody that detects human MOSPD2. It targets an epitope within the MSP domain.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • MOSPD2
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight~56 kDa observed; 59.75 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in human pancreas tissue sections.

      Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected MOSPD2 in human pancreas tissue sections.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABF2202-25UG 04061841844501

      Documentation

      Anti-MOSPD2 Antibody, clone 1MOS‐4E10 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-MOSPD2 Antibody, clone 1MOS‐4E10 Certificates of Analysis

      TitleLot Number
      Anti-MOSPD2, clone 1MOS‐4E10 - Q3437414 Q3437414

      References

      Reference overviewPub Med ID
      Identification of MOSPD2, a novel scaffold for endoplasmic reticulum membrane contact sites.
      Di Mattia T, Wilhelm LP, Ikhlef S, Wendling C, Spehner D, Nominé Y, Giordano F, Mathelin C, Drin G, Tomasetto C, Alpy F.
      EMBO Rep  19(7)  e45453  2018

      Show Abstract       		29858488 29858488