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MAB4163 Anti-MDR1 Antibody, extracellular human specific Pgp, clone MC57

Anti-MDR1 Antibody, extracellular human specific Pgp, clone MC57 detects level of MDR1 & has been published & validated for use in FC, IH, IH(P).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Metabolism Research Sub-Category: Toxicology & Drug Resistance Gene Symbol: ABCB1, PGY1, MGC163296, GP170, ABC20, CD243, P-gp, MDR1, CLCS, EC 3.6.3.44 UniProt Number: P08183
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MAB4163
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFC, IHC, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB4163
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-MDR1 Antibody, extracellular human specific Pgp, clone MC57
      Alternate Names
      • P-glycoprotein
      • CD243
      • p170
      • Pgp
      References
      Product Information
      FormatPurified
      PresentationPurified immunoglobulin from Protein A Sepharose chromatography. Liquid in 0.02M PB, pH 7.6, 0.25M NaCl containing 0.1% sodium azide.
      Quality LevelMQ300
      Applications
      ApplicationAnti-MDR1 Antibody, extracellular human specific Pgp, clone MC57 detects level of MDR1 & has been published & validated for use in FC, IH, IH(P).
      Key Applications
      • Flow Cytometry
      • Immunohistochemistry
      • Immunohistochemistry (Paraffin)
      Application NotesFlow Cytometry

      Immunohistochemistry

      Immunohistochemistry on paraffin sections

      Functional Experiments

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenLiving intact human multidrug-resistant cells
      Epitopeextracellular human specific Pgp
      CloneMC57
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityMDR-1 clone MC57 recgonizes the inactivated form of Pgp and recognizes the conformational epitope in Immunohistochemistry on paraffin sections.
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
      Gene Symbol
      • ABCB1
      • PGY1
      • MGC163296
      • GP170
      • ABC20
      • CD243
      • P-gp
      • MDR1
      • CLCS
      • EC 3.6.3.44
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P08183 # Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
      SIZE: 1280 amino acids; 141463 Da
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Expressed in liver, kidney, small intestine and brain.
      SIMILARITY: SwissProt: P08183 ## Belongs to the ABC transporter family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. & Contains 2 ABC transmembrane type-1 domains. & Contains 2 ABC transporter domains.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 6 months.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MAB4163 08436037125614

      Documentation

      Anti-MDR1 Antibody, extracellular human specific Pgp, clone MC57 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-MDR1 Antibody, extracellular human specific Pgp, clone MC57 Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-MDR-1 [P-GLYCOPROTEIN] - 3026850 3026850
      MOUSE ANTI-MDR-1 [P-GLYCOPROTEIN] - 3434794 3434794
      MOUSE ANTI-MDR-1 [P-GLYCOPROTEIN] - 3465453 3465453
      MOUSE ANTI-MDR-1 [P-GLYCOPROTEIN] - 3793697 3793697
      MOUSE ANTI-MDR-1 [P-GLYCOPROTEIN] - 4076647 4076647
      MOUSE ANTI-MDR-1 [P-GLYCOPROTEIN] - 4080473 4080473
      MOUSE ANTI-MDR-1 [P-GLYCOPROTEIN] -2782551 2782551

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies