Millipore Sigma Vibrant Logo

05-337 Anti-MARCKS Antibody, clone 2F12

View Products on Sigmaaldrich.com
05-337
200 µL  
Price could not be retrieved
Minimum Quantity is a multiple of
Maximum Quantity is
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited Availability
Limited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      Special Offers

       

      Contact Customer Service

      Overview

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      B, HIP, WBMAscitesMonoclonal Antibody
      Description
      Catalogue Number05-337
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-MARCKS Antibody, clone 2F12
      Product Information
      FormatAscites
      Presentationmouse ascites containing 0.05% sodium azide
      Quality LevelMQ100
      Applications
      ApplicationAnti-MARCKS Antibody, clone 2F12 detects level of MARCKS & has been published & validated for use in IP & WB.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      ImmunogenPurified recombinant human MARCKS; Epitope mapped to the carboxyl-terminal.
      Clone2F12
      HostMouse
      SpecificityMARCKS
      IsotypeIgG1
      Species Reactivity
      • Bovine
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis.
      Gene Symbol
      • MARCKS
      • 80K-L
      • MACS
      • PRKCSL
      • FLJ14368
      • phosphomyristin
      • MRACKS
      • PKCSL
      • FLJ90045
      Purification MethodAscites
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P29966 # MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.
      SIZE: 332 amino acids; 31555 Da
      PTM: Phosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity.
      SIMILARITY: SwissProt: P29966 ## Belongs to the MARCKS family.
      Molecular Weightnone given
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on bovine brain extract
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -20°C
      Packaging Information
      Material Size200 µL
      Global Trade Item Number
      Catalogue Number GTIN
      05-337 08436037125508