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ABE1800-25UG Anti-La-Related Protein 1

Anti-La-Related Protein 1 Antibody, Cat. No. ABE1800-25UG, is a highly specific rabbit polyclonal antibody, that targets La-related protein 1 and has been tested in Western Blotting and Immunocytochemistry and Immunohistochemistry (Paraffin).

Anti-La-Related Protein 1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Gene Symbol: LARP1, KIAA0731, LARP UniProt Number: Q6PKG0
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ABE1800-25UG
25 μg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, ICC, IH(P)RbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABE1800-25UG
      DescriptionAnti-La-Related Protein 1
      Alternate Names
      • La ribonucleoprotein domain family member 1
      Background InformationLa-related protein 1 (UniProt: Q6PKG0; also known as La ribonucleoprotein domain family member 1) is encoded by the LARP1 (also known as KIAA0731, LARP) gene (Gene ID: 23367) in human. La-related protein 1 is a cytoplasmic RNA-binding protein that promotes translation of specific classes of mRNAs downstream of the mTORC1 complex. It contains 1 HTH La-type RNA-binding domain and it associates with the mRNA 5'cap in an mTOR-dependent manner and associates with mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding for ribosomal proteins and several components of the translation machinery. La-related protein 1 is also shown to associates with actively translating ribosomes via interaction with polyadenylate-binding protein 1 (PABPC1/PABP) and stimulates translation of mRNAs containing a 5'TOP, thereby regulating cell growth and proliferation. It is shown to be up-regulated in a number of hepatocellular carcinoma cell lines and liver cancer lesions, as well as in patients with hepatocellular carcinoma with a lower survival rate. (Ref.: Fonseca, BD et al. (2015). J. Biol. Chem. 290(26):15996-6020).
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-La-Related Protein 1 Antibody, Cat. No. ABE1800-25UG, is a highly specific rabbit polyclonal antibody, that targets La-related protein 1 and has been tested in Western Blotting and Immunocytochemistry and Immunohistochemistry (Paraffin).
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      • Immunohistochemistry (Paraffin)
      Application NotesImmunocytochemistry Analysis: A 1:50 dilution from a representative lot detected La-Related Protein 1 in HEK293 cells.

      Immunohistochemistry Analysis: A 1:250-1,000 dilution from a representative lot detected La-Related Protein 1 in human cerebellum, human tonsil, and human pancreas tissues.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to 15 amino acids from the N-termnal half of huamn La-related protein 1.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • LARP1
      • KIAA0731
      • LARP
      Purification MethodAffinity Purified
      UniProt Number
      Molecular Weight123 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HEK293 cell lysate.
      Western Blotting Analysis: 0.2 µg/mL of this antibody detected La-Related Protein 1 in 10 µg of HEK293 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABE1800-25UG 04054839453748