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MABS1816 Anti-LRIG1 Antibody, clone 2D1.1

Anti-LRIG1 Antibody, clone 2D1.1, Cat. No. MABS1816, is a mouse monoclonal antibody that targets human Leucine-rich repeats and immunoglobulin-like domains protein 1 (LRIG1) and has been tested for use in Western Blotting.

Anti-LRIG1 Antibody, clone 2D1.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Gene Symbol: LRIG1, LIG1 UniProt Number: Q96JA1
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MABS1816
100 μg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABS1816
      DescriptionAnti-LRIG1 Antibody, clone 2D1.1
      Alternate Names
      • Leucine-rich repeats and immunoglobulin-like domains protein 1
      • LIG-1
      Background InformationLeucine-rich repeats and immunoglobulin-like domains protein 1 (UniProt: Q96JA1; also known as LIG-1) is encoded by the LRIG1 (also known as LIG1) gene (Gene ID: 26018) in human. LIG-1 is a widely expressed single-pass type I membrane protein that acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. LIG-1 contains 3 Ig-like C2-type (immunoglobulin-like) domains, 15 LRR (leucine-rich) repeats, 1 1 LRRCT domain, and 1LRRNT domain. The LRRs and the Ig-domains are each sufficient for EGFR/ERBB1 binding and this interaction is abolished only when these two domains are deleted. LIG-1 is highly expressed by intestinal stem cells and controls the size of the intestinal stem-cell niche by regulating the amplitude of growth-factor signaling. It is also reported to control stem-cell proliferation in epidermis. LIG-1 is reported to be expressed in a gradient with highest levels in intestinal stem cells and it is absent from Paneth cells. About one-third of all cells in the intestinal crypts are shown to express LIG-1. (Ref.: Wong VWY., et al. (2012). Nat. Cell Biol. 14(4); 401-408).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-LRIG1 Antibody, clone 2D1.1, Cat. No. MABS1816, is a mouse monoclonal antibody that targets human Leucine-rich repeats and immunoglobulin-like domains protein 1 (LRIG1) and has been tested for use in Western Blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenGST/His-tagged recombinant fragment corresponding to 134 amino acids from the C-terminal end of human Leucine-rich repeats and immunoglobulin-like domains protein 1 (LRIG1).
      Clone2D1.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 2D1.1 detects Leucine-rich repeats and immunoglobulin-like domains protein 1 (LIG-1) in human. It targets an epitope within 134 amino acids from the C-terminal end.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • LRIG1
      • LIG1
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight~150 kDa observed; 119.11 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in LNCaP cell lysate.

      Western Blotting Analysis: 1 µg/mL of this antibody detected LRIG1 in 10 µg of LNCaP cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABS1816 04054839201417