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ABS1485 Anti-Kinesin-like protein KIF7

This rabbit polyclonal Anti-Kinesin-like protein KIF7 Antibody, Cat. No. ABS1485 is validated for use in Western Blotting for the detection of Kinesin-like protein KIF7.

Anti-Kinesin-like protein KIF7 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Gene Symbol: KIF7, UNQ340/PRO539 UniProt Number: Q2M1P5
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ABS1485
100 μg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABS1485
      DescriptionAnti-Kinesin-like protein KIF7
      Alternate Names
      • KIF7
      Background InformationKinesin-like protein KIF7 (UniProt: Q2M1P5; also known as KIF7) is encoded by the KIF7 (also known as UNQ340/PRO539) gene (Gene ID: 374654) in human. KIF7 is a member of kinesin-4 family that is essential for hedgehog signaling regulation. It localizes to cilia tips, the site of microtubule plus-ends, where it limits cilia length and controls cilia structure. KIF7 is required for the normal structure of primary cilia and in the absence of KIF7, cilia are long and unstable. KIF7 acts as both a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms. It negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator Gli2 in the absence of ligand and positively regulates Shh signaling by preventing the processing of the Gli3 into its repressor form. KIF7 physically interacts with Gli transcription factors and controls their proteolysis and stability. Defects in KIF7 gene can lead to ciliary dysfunction, which result in a broad spectrum of disorders, collectively termed ciliopathies, including the Bardet-Biedl syndrome, a syndrome characterized by severe pigmentary retinopathy, early-onset obesity, polydactyly, hypogenitalism, renal malformation, and mental retardation. (Ref.: Cheung. H.O. et al. (2009). Sci. Signal. 2(76):ra29).
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis rabbit polyclonal Anti-Kinesin-like protein KIF7 Antibody, Cat. No. ABS1485 is validated for use in Western Blotting for the detection of Kinesin-like protein KIF7.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-cojugated linear peptide corresponding to 14 amino acid fragment from the C-terminal region of human Kinesin-like protein KIF7.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityDetects Kinesin-like protein KIF7 in HEK293 cells by Western blotting.
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • KIF7
      • UNQ340/PRO539
      Purification MethodAffinity Purified
      UniProt Number
      Molecular Weight~160 kDa observed; 150.59 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HEK293 cell lysates.

      Western Blotting Analysis: 2 µg/mL of this antibody detected Kinesin-like protein KIF7 in 10 µg of HEK293 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABS1485 04054839153143