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MABF2295-25UG Anti-IL-12 p40 Antibody, clone 11B10

Anti-IL-12 p40, clone 11B10, Cat. No. MABF229, is a mouse monoclonal antibody that detects Interleukin-12 subunit beta and has been tested for use in Flow Cytometry and Immunohistochemistry (Paraffin).

MABF2295-25UG
25 μg  
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      Overview

      Replacement Information
      Description
      Catalogue NumberMABF2295-25UG
      DescriptionAnti-IL-12 p40 Antibody, clone 11B10
      Alternate Names
      • Interleukin-12 subunit beta
      • IL-12B
      • Cytotoxic lymphocyte maturation factor 40 kDa subunit
      • CLMF p40
      • IL-12 subunit p40
      • NK cell stimulatory factor chain 2
      • NKSF2
      Background InformationInterleukin-12 subunit beta (UniProt: P29460; also known as IL-12B, Cytotoxic lymphocyte maturation factor 40 kDa subunit, CLMF p40, IL-12 subunit p40, NK cell stimulatory factor chain 2, NKSF2) is encoded by the IL12B (also known as NKSF2) gene (Gene ID: 3593) in human. IL-12 is a heterodimeric protein composed of the p35 and p40 subunits. It is secreted by activated monocytes, macrophages, and dendritic cells, and has been shown to target naïve, resting CD4+ T cells to promote their proliferation and secretion of cytokines. The IL-12 p40 subunit is a secreted protein, which is synthesized with a signal peptide that is subsequently cleaved off to generate the mature form. It can homodimerize and the homodimeric form is shown to be about 25 to 50-fold more active than the monomer in competing with native IL-12 in receptor binding. IL-12 p40 can act as a growth factor for activated T and NK cells and can enhance the lytic activity of NK/lymphokine-activated killer cells and stimulate the production of IFN-gamma by resting peripheral blood mononuclear cells. It is also reported to associates with IL23A to form the IL-23 interleukin that functions in innate and adaptive immunity. (Ref.: Stallmach, A., et al. (2004). Gut. 53(3): 339-345).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in PBS with 0.05% sodium azide.
      Applications
      ApplicationAnti-IL-12 p40, clone 11B10, Cat. No. MABF229, is a mouse monoclonal antibody that detects Interleukin-12 subunit beta and has been tested for use in Flow Cytometry and Immunohistochemistry (Paraffin).
      Key Applications
      • Immunohistochemistry (Paraffin)
      • Flow Cytometry
      Application NotesFlow Cytometry Analysis: 1 µg from a representative lot detected IL-12 p40 in one million Jurkat cells.
      Biological Information
      ImmunogenHis-tagged full-length human recombinant Interleukin-12 subunit beta (IL12 p40).
      Clone11B10
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 11B10 is a mouse monoclonal antibody that targets human Interleukin-12 p40 subunit.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • IL12B
      • NKSF2
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight37.17 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry (Paraffin) in human tonsil tissue sections.

      Immunohistochemistry (Paraffin) Analysis: A 1:50 dilution of this antibody detected IL-12 p40 in human tonsil tissue sections.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABF2295-25UG 04061841276630