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ABN1008 Anti-ENTPD1 Antibody

This Anti-ENTPD1 Antibody is validated for use in Western Blotting, Flow Cytometry for the detection of ENTPD1.

Anti-ENTPD1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: ENTPD1, CD39 UniProt Number: P49961
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ABN1008
100 μg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, FCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABN1008
      DescriptionAnti-ENTPD1 Antibody
      Alternate Names
      • Ectonucleoside triphosphate diphosphohydrolase 1
      • NTPDase 1
      • Ecto-ATP diphosphohydrolase 1
      • Ecto-ATPDase 1
      • Ecto-ATPase 1
      • Ecto-apyrase
      • Lymphoid cell activation antigen
      • CD39
      • ENTPD1
      • NTPDase1
      Background InformationEctonucleoside triphosphate diphosphohydrolase 1 (EC:3.6.1.5; UniProt P49961; also known as CD39, Ecto-apyrase, Ecto-ATP diphosphohydrolase 1, Ecto-ATPDase 1, Ecto-ATPase 1, Lymphoid cell activation antigen, NTPDase 1) is encoded by the ENTPD1 (also known as CD39, SPG64) gene (Gene ID 953) in human. CD39 is a cell surface nucleotide-metabolizing enzyme that hydrolyzes extracellular purine NTP and NDP. CD39 is a putative marker for B-cell activation and its expression is also observed on NK-cells, dendritic cells, T-cells, and vascular endothelial cells. CD39 is a known inhibitor of ADP-induced platelet aggregation and may also play a role in angiogenesis. E. coli infection is reported to induce CD39 promoter activity in macrophages, resulting in an upregulated CD39 expression during sepsis in mice, while CD39 knockdown increases mortality among mice with polymicrobial sepsis.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-ENTPD1 Antibody is validated for use in Western Blotting, Flow Cytometry for the detection of ENTPD1.
      Key Applications
      • Western Blotting
      • Flow Cytometry
      Application NotesWestern Blotting Analysis: 2.0 µg/mL from a representative lot detected ENTPD1 in 10 µg of human spleen and Jurkat cell lystaes.
      Flow Cytometry Analysis: 1.0 µg of this antibody from a representative lot detected ENTPD1 in 1X10E6 Jurkat cells.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the extracellular domain of human ENTPD1.
      Epitopeextracellular domain
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityExpeccted to react with all six spliced isoforms, including the Vascular and the Placenta I&II isoforms.
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with Primate based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ENTPD1
      • CD39
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~65 kDa observed when using human placenta tissue lysates. Glycosylated target band(s) will appear larger than the calculated molecular weights of 58.0 kDa (Isoform 1/Vascular), 58.7 kDa ((Isoform 2/Placenta I), 34.2 kDa (Isoform 3/Placenta II), 42.7 kDa (Isoform 4), 46.2 kDa (Isoform 5), and 59.3 kDa (Isoform 6). Uncharacterized band(s) may appear in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human placenta cell lysate.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected ENTPD1 in 10 µg of human placenta cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABN1008 04055977277340