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ABC451 Anti-Dihydropyrimidine dehydrogenase/DPYD Antibody

This Anti-Dihydropyrimidine dehydrogenase/DPYD Antibody is validated for use in Western Blotting and Immunohistochemistry for the detection of Dihydropyrimidine dehydrogenase/DPYD.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: DPYD UniProt Number: Q12882
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ABC451
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABC451
      DescriptionAnti-Dihydropyrimidine dehydrogenase/DPYD Antibody
      Alternate Names
      • Dihydropyrimidine dehydrogenase [NADP(+)]
      • DHPDHase
      • DPD
      • Dihydrothymine dehydrogenase
      • Dihydrouracil dehydrogenase
      • DPYD
      Background InformationDPYD is an important enzyme involved in pyrimidine base degradation and catabolism. DPYD catalyzes the reduction of uracil and thymine and also is a critical enzyme in the degradation of the chemotherapeutic drug 5-fluoruracil. DPYD is expressed in most cells and has highest activity in the liver and monocytes. Mutations in DPYD give rise to a range of symptoms and syndromes in patients ranging from no symptoms to highly convulsive and mental retardation caused by excessive amounts of uracil or thymine present in the blood. Because of its ability to degrade 5-fluorouracil, DPYD is studied as a cancer marker and a measure of therapeutic effects in many cancers. Recent research also shows that DPYD levels in the liver are regulated via microRNA interactions and an offer a new opportunity for modulation of this critical enzyme in health and disease.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Dihydropyrimidine dehydrogenase/DPYD Antibody is validated for use in Western Blotting and Immunohistochemistry for the detection of Dihydropyrimidine dehydrogenase/DPYD.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesWestern Blotting Analysis: 2.0 µg/mL from a representative lot detected Dihydropyrimidine dehydrogenase/DPYD in 10 µg of human liver tissue lysate.
      Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Dihydropyrimidine dehydrogenase/DPYD in human liver tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human Dihydropyrimidine dehydrogenase/DPYD near the N-terminus.
      EpitopeNear N-terminus
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with Primate, Bovine, Porcine, Horse based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • DPYD
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~110 kDa observed. Uncharacterized band at ~47 kDa may be observed in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human small intestine tissue lysate.

      Western Blotting Analysis: 2.0 µg/mL of this antibody detected Dihydropyrimidine dehydrogenase/DPYD in 10 µg of human small intestine tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABC451 04055977109191