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AB5840-I-25UG Anti-Dab1

Anti-Dab1, Cat. No. AB5840-I, is a highly specific rabbit polyclonal antibody that targets Disabled homolog 1 and has been tested in Immunohistochemistry (Paraffin) and Western Blotting.

Anti-Dab1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Gene Symbol: Dab1 UniProt Number: P97318
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AB5840-I-25UG
25 μg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MWB, IH(P)RbPurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB5840-I-25UG
      DescriptionAnti-Dab1
      Alternate Names
      • Disabled homolog 1
      Background InformationDisabled homolog 1 (UniProt: P97318; also known as DAB1) is encoded by the Dab1 gene (Gene ID: 13131) in murine species. Dab 1 is mainly expressed in the brain and serves as an adapter molecule involved in neural development where it is reported to direct the migration of cortical neurons past previously formed neurons to reach their proper layer. DAB1 is can be phosphorylated on Tyr198, Tyr220, and Tyr232 upon reelin induction in embryonic neurons. It can also be phosphorylated on Ser524, but this phosphorylation is independent of reelin signaling. Tyrosine phosphorylation of DAB1 by Src family tyrosine kinases is considered to be the most critical downstream event in Reelin signaling. DAB1 contains a phosphotyrosine interaction domain (PID) (aa 36-189), which specifically binds to the Asn-Pro-Xaa-Tyr(P) motif found in many tyrosine-phosphorylated proteins. Seven different isoforms of Dab1 have been identified that are generated via alternative splicing.
      References
      Product Information
      FormatPurified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-Dab1, Cat. No. AB5840-I, is a highly specific rabbit polyclonal antibody that targets Disabled homolog 1 and has been tested in Immunohistochemistry (Paraffin) and Western Blotting.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:250 dilution from a representative lot detected Dab1 in mouse cerebral cortex tissue sections.
      Biological Information
      ImmunogenGST-tagged recombinant fragment corresponding to 156 amino acids from the C-terminal half of murine Disabled homolog 1 (Dab1).
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityThis rabbit polyclonal antibody detects murine Disabled homolog 1 (Dab1). It targets an epitope within 156 amino acids from the C-terminal half.
      Species Reactivity
      • Mouse
      Species Reactivity NoteMouse.
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • Dab1
      Purification MethodAffinity Purified
      UniProt Number
      Molecular Weight~64 kDa observed; 63.58 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse brain tissue lysate.
      Western Blotting Analysis: 2 µg/mL of this antibody detected Dab1 in 10 µg of m ouse brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB5840-I-25UG 04054839518683