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AB5638P Anti-Cannabinoid Receptor 1 Antibody, CT

Anti-Cannabinoid Receptor 1 Antibody, C-terminus is an antibody against Cannabinoid Receptor 1 for use in ELISA & WB.

Anti-Cannabinoid Receptor 1 Antibody, CT MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neuroinflammation & Pain, Neurotransmitters & Receptors Gene Symbol: CNR1, CNR, CANN6, CB1A, CB1, CB1K5, CB-R UniProt Number: P21554
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AB5638P
50 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, RELISA, WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB5638P
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Cannabinoid Receptor 1 Antibody, CT
      Alternate Names
      • CB1
      Background InformationCB1 is a protein that is one of two cannabinoid receptors (CB1 CB2). Cannabinoid principally delta-9-tetrahydrocannabinol (THC) and its synthetic analogs, are the active psychoactive compounds present is marijuana. These cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptors which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Three splice variants have been found for this gene. CB1 is primarily located in brain, and CB2 is found macrophages.
      References
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified immunoglobulin. Liquid in phosphate buffered saline containing 0.1% BSA.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Cannabinoid Receptor 1 Antibody, C-terminus is an antibody against Cannabinoid Receptor 1 for use in ELISA & WB.
      Key Applications
      • ELISA
      • Western Blotting
      Application NotesWestern blot: 1-10 μg/mL using ECL. Expected sizes are ~60kDa and 80-84kDa under reducing conditions.

      Immunohistochemistry: not tested. It is recommended that the antibody be tried at 2-10 μg/mL on paraformaldehyde fixed tissue.

      ELISA: 1:10,000-1:100,000 using 50-100 ng control peptide (Catalog number AG213) per well.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenA 20 amino acid peptide sequence near the cytoplasmic, C-terminus of rat CB1 (Gerard et al. 1991; Gerard et al.

      1990; Shire et al. 1995; Matsuda et al. 1990; Ho et al. 1996; Chakraborty et al. 1995).
      EpitopeC-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes rat Cannabinoid Receptor 1 (CB1). The immunogen shows no significant sequence homology with CB2 or other receptors.

      SPECIES REACTIVITIES: The immunogen peptide is 100% conserved mouse, 94% in monkey and human, 88% in zebra finch, 75% in feline and newt, (salamander) and 73% in puffer fish. Reactivity with other species has not been confirmed.
      Species Reactivity
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a protein that is one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the family of guanine-nucleotide-binding protein (G-protein) coupled receptors which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Two transcript variants encoding different isoforms have been described for this gene.
      Gene Symbol
      • CNR1
      • CNR
      • CANN6
      • CB1A
      • CB1
      • CB1K5
      • CB-R
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P21554 # Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Isoform 2 and isoform 3 have altered ligand binding.
      SIZE: 472 amino acids; 52858 Da
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Widely expressed.
      SIMILARITY: SwissProt: P21554 ## Belongs to the G-protein coupled receptor 1 family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB5638P 04053252471216

      Documentation

      Anti-Cannabinoid Receptor 1 Antibody, CT SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Cannabinoid Receptor 1 Antibody, CT Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-CANNABINOID RECEPTOR 1 (CB1) - 3528103 3528103
      RABBIT ANTI-CANNABINOID RECEPTOR 1 (CB1) - 3862516 3862516
      RABBIT ANTI-CANNABINOID RECEPTOR 1 (CB1) AFFINITY PURIFIED POLYCLONAL ANTIBODY 3058478
      RABBIT ANTI-CANNABINOID RECEPTOR 1 (CB1) AFFINITY PURIFIED POLYCLONAL ANTIBODY 2869803
      RABBIT ANTI-CANNABINOID RECEPTOR 1 (CB1) AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2070086 2070086
      RABBIT ANTI-CANNABINOID RECEPTOR 1 (CB1) AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2270543 2270543

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies