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MABF1070 Anti-C-Reactive Protein Antibody, clone 2A8.1

This mouse monoclonal Anti-C-Reactive Protein, clone 2A8.1 Antibody, Cat. No. MABF1070 is validated for use in Western Blotting and Immunohistochemistry (Paraffin), for the detection of C-Reactive protein.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Gene Symbol: CRP, PTX1 UniProt Number: P02741
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MABF1070
100 μg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIH(P), WBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABF1070
      DescriptionAnti-C-Reactive Protein Antibody, clone 2A8.1
      Alternate Names
      • C-reactive protein
      Background InformationC-reactive protein (UniProt P02741) is encoded by the CRP (also known as PTX1) gene (Gene ID 1401) in human. CRP is the classical acute phase reactant produced by the liver and its circulating concentration increases rapidly in a cytokine-mediated response to tissue injury, infection, and inflammation. It is an annular, pentameric protein that binds to lysophosphatidylcholine expressed on the surface of dead or dying cells and bacteria in order to activate the complement system via the C1Q complex. Interleukin-6 (IL-6), produced by macrophages in response to injury and infection, is a major trigger for the synthesis of CRP by the liver. It plays a major role in early host defense by promoting agglutination, bacterial capsular swelling, phagocytosis, and complement fixation through its calcium-dependent binding to phosphorylcholine. It can also interact with DNA and histones and scavenge nuclear material released from damaged circulating cells.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis mouse monoclonal Anti-C-Reactive Protein, clone 2A8.1 Antibody, Cat. No. MABF1070 is validated for use in Western Blotting and Immunohistochemistry (Paraffin), for the detection of C-Reactive protein.
      Key Applications
      • Immunohistochemistry (Paraffin)
      • Western Blotting
      Application NotesImmunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected C-reactive protein in human cerebral cortex, kidney, and liver tissue sections.
      Biological Information
      ImmunogenGST-tagged recombinant human C-reactive protein C-terminal fragment.
      Clone2A8.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 2A8.1 targets an epitope within the C-terminal half of human C-reactive protein.
      IsotypeIgG2bκ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CRP
      • PTX1
      Purification MethodProtein G purified.
      UniProt Number
      Molecular Weight~25 kDa observed. 25.04/23.05 kDa (with/without signal peptide a.a. 1-18 sequence) calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human liver tissue lysate.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected C-reactive protein in 10 µg of human liver tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABF1070 04054839112409