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MABC523 Anti-BCL7A Antibody, clone 15C

Anti-BCL7A Antibody, clone 15C is a highly specific mouse monoclonal antibody, that targets B-cell CLL/lymphoma 7 protein family member A & has been tested in IHC & Immunofluorescence.

Anti-BCL7A Antibody, clone 15C MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Cell Cycle, DNA Replication & Repair Gene Symbol: BCL7A UniProt Number: Q4VC05
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MABC523
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIHC, IFMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABC523
      DescriptionAnti-BCL7A Antibody, clone 15C
      Alternate Names
      • B-cell CLL/lymphoma 7 protein family member A
      Background InformationThe protein named B-cell CLL/lymphoma 7 protein family member A or BCL7A and encoded by the human gene named BCL7A is protein that interacts with SWI/SNF components (a nucleosome remodeling complex), implicating that BCL7A’s normal function involves chromatin remodeling. BCL7A was original cloned from a chromosomal translocation in a Burkitt lymphoma cell line and appears to be important in B cell malignancy. Overexpression of BCL7A is associated with germinal center phenotype formation in B cells and BCL7A expression is up regulated in CLL and multiple myeloma but lower in mycosis fungoides and peripheral T cell lymphoma. Recent research indicates that BCL7A was expressed at the pro B and T cell stage and persisted through the pre-B and mature B cell stages. BCL7A expression was maintained in late B cell differentiation but down-regulated in late plasma cells and mature T cells. In haematological malignancies, BCL7A protein was present in the majority of precursor and mature B cell lymphomas with increased expression amongst GC-related lymphomas. Mature T cell malignancies did not express BCL7A.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-BCL7A Antibody, clone 15C is a highly specific mouse monoclonal antibody, that targets B-cell CLL/lymphoma 7 protein family member A & has been tested in IHC & Immunofluorescence.
      Key Applications
      • Immunohistochemistry
      • Immunofluorescence
      Application NotesImmunofluorescence Analysis: A 1:10 dilution from a representative lot detected BCL7A in human tonsil tissue (Prof. G. Roncador, CNIO, Madrid).

      Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected BCL7A in human lymph node, spleen, and thymus tissue (Prof. G. Roncador, CNIO, Madrid).

      Immunohistochemistry Analysis: A representative lot detected BCL7A in HEK293 cells transfected with BCL7A, and not in HEK293 cells transfected with SPIB protein (Prof. G. Roncador, CNIO, Madrid).
      Biological Information
      ImmunogenHis-tagged recombinant protein corresponding to human BCL7A.
      Clone15C
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • BCL7A
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight23 kDa calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in human tonsil and colon tissues.

      Immunohistochemistry Analysis: A 1:500 dilution of this antibody detected BCL7A in human tonsil and colon tissues.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABC523 04053252934940

      Documentation

      Anti-BCL7A Antibody, clone 15C SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-BCL7A Antibody, clone 15C Certificates of Analysis

      TitleLot Number
      Anti-BCL7A, clone 15C - 3272813 3272813
      Anti-BCL7A, clone 15C - 3448840 3448840
      Anti-BCL7A, clone 15C - 3600557 3600557
      Anti-BCL7A, clone 15C - 3836459 3836459
      Anti-BCL7A, clone 15C - Q2303827 Q2303827

      References

      Reference overviewPub Med ID
      British journal of haematology
      Ramos-Medina, R; Montes-Moreno, S; Maestre, L; Cañamero, M; Rodríguez-Pinilla, M; Martínez-Torrecuadrada, J; Piris, MÁ; Majid, A; Dyer, MJ; Pulford, K; Roncador, G
      British journal of haematology  160  106-9  2013

      		23043359 23043359

      Brochure

      Title
      New Products Flyer- Feb 2014 - Vol 1