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MABT1352-100UG Anti-Aquaporin 11 Antibody, clone 8H9

Anti-Aquaporin 11, clone 8H9, Cat. No. MABT1352, is a highly specific mouse monoclonal antibody that targets Aquaporin-11 and has been tested for use in Immunohistochemistry (Paraffin), Immunoprecipitation, and Western Blotting.

MABT1352-100UG
100 μg  
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      Overview

      Replacement Information
      Description
      Catalogue NumberMABT1352-100UG
      DescriptionAnti-Aquaporin 11 Antibody, clone 8H9
      Alternate Names
      • AQP-11
      Background InformationAquaporin-11 (UniProt: Q8NBQ7; also known as AQP-11) is encoded by the AQP11 (also known as AQPX1) gene (Gene ID: 282679) in human. Aquaporins are a family of 13 integral membrane proteins that are essential for water transport across membranes. AQP-11 is a multi-pass membrane protein that displays several unique features. Human AQP-11 displays high degree of homology with mouse, rat and horse AQP-11. The water permeability of AQP-11 is shown to be about 8-fold lower than AQP-1 and it is reversibly inhibited by mercury ions. It is shown to be involved in slow, but constant water movement across the membrane. AQP-11 shares two tandem repeats with other aquaporins, each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA; aa 99-101 and 216-218). However, the first tandem repeat of AQP-11 contains cysteine instead of alanine. AQP-11 is detected in photoreceptor cells and it shown to be down-regulated in retina in cases of uveitis. Clone 8H9 exhibits binding to a conserved linear epitope of mammalian AQP-11. (Ref.: Amann, B., et al. (2016). Int. J. Mol. Sci,17(7): 1145; Yakata, K., et al. (2011). J. Struct. Biol. 174(2); 315-320).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-Aquaporin 11, clone 8H9, Cat. No. MABT1352, is a highly specific mouse monoclonal antibody that targets Aquaporin-11 and has been tested for use in Immunohistochemistry (Paraffin), Immunoprecipitation, and Western Blotting.
      Key Applications
      • Immunohistochemistry (Paraffin)
      • Immunoprecipitation
      • Western Blotting
      Application NotesImmunohistochemistry (Paraffin) Analysis: A 1:50 dilution from a representative lot detected Aquaporin-11 in mouse retina tissue sections.

      Immunoprecipitation Analysis: A representative immunoprecipitated Aquaporin-11 in Immunoprecipitation applications (Deeg, C.A., et. al. (2016). J Neuroinflammation. 13(1):89).

      Immunohistochemistry Analysis: A representative lot detected Aquaporin-11 in Immunohistochemistry applications (Deeg, C.A., et. al. (2016). J Neuroinflammation. 13(1):89).

      Immunohistochemistry (Paraffin) Analysis: A representative lot detected Aquaporin-11 in Immunohistochemistry applications (Amann, B., et. al. (2016). Int J Mol Sci. 17(7)).

      Western Blotting Analysis: A representative lot detected Aquaporin-11 in Western Blotting applications (Deeg, C.A., et. al. (2016). J Neuroinflammation. 13(1):89).
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to 12 amino acids from the C-terminal region of human Aquaporin-11.
      Clone8H9
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 8H9 specifically detects Aquaporin-11 in multiple species. It targets an epitope with in 12 amino acids from the C-terminal region.
      IsotypeIgG1κ
      Species Reactivity
      • Mouse
      • Horse
      • Human
      • Rat
      Species Reactivity NoteHuman, Horse, Mouse, Rat.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • AQP11
      • AQPX1
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight30.20 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry (Paraffin) in human retina tissue sections.

      Immunohistochemistry (Paraffin) Analysis: A 1:50 dilution of this antibody detected Aquaporin-11 in human retina tissue sections.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABT1352-100UG 04054839659942