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116816 Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 8-Bromo-, Rp-Isomer, Sodium Salt - Calbiochem

A potent, cell-permeable, and reversible metabolically-stable cAMP antagonist that inhibits cAMP-dependent protein kinase and shows preference for PKA type I.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Rp-8-Br-cAMPS, Na, PKA Inhibitor VI

Primary Target: PKA 1
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116816
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₀H₁₀BrN₅O₅PS · Na

Pricing & Availability

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116816-5UMOL
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      		 Plastic ampoule 5 umol
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      Description
      OverviewA potent, cell-permeable, and reversible metabolically-stable cAMP antagonist that inhibits cAMP-dependent protein kinase and shows preference for PKA type I. More lipophilic than cAMP antagonist Rp-cAMPS (Cat. No. 116814).
      Note: 5 µmol = 2.23 mg.
      Catalogue Number116816
      Brand Family Calbiochem®
      SynonymsRp-8-Br-cAMPS, Na, PKA Inhibitor VI
      References
      ReferencesCalaghan, S.C., et al. 1999. Pflugers Arch. 437, 780.
      Gjertsen, B.T., et al. 1995. J. Biol. Chem. 270, 20599.
      Yokozaki, H., et al. 1992. Cancer Res. 52, 2504.
      Dostmann, W.R. et al. 1990. J. Biol. Chem. 265, 10484.
      Product Information
      ATP CompetitiveN
      DeclarationSold under license of Patent DE 3,802,865.4 issued to BIOLOG LSI.
      FormLyophilized
      Hill FormulaC₁₀H₁₀BrN₅O₅PS · Na
      Chemical formulaC₁₀H₁₀BrN₅O₅PS · Na
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPKA 1
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      116816-5UMOL 04055977208269

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 8-Bromo-, Rp-Isomer, Sodium Salt - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 8-Bromo-, Rp-Isomer, Sodium Salt - Calbiochem Certificates of Analysis

      TitleLot Number
      116816

      References

      Reference overview
      Calaghan, S.C., et al. 1999. Pflugers Arch. 437, 780.
      Gjertsen, B.T., et al. 1995. J. Biol. Chem. 270, 20599.
      Yokozaki, H., et al. 1992. Cancer Res. 52, 2504.
      Dostmann, W.R. et al. 1990. J. Biol. Chem. 265, 10484.

      Brochure

      Title
      Inhibitor Sourcebook 3rd Edition

      Citations

      Title
    • Ralf Gutzmer, et al. (2005) Histamine H4 receptor stimulation suppresses IL-12p70 production and mediates chemotaxis in human monocyte-derived dendritic cells. Journal of Immunology 5224-5232.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-January-2010 RFH
      SynonymsRp-8-Br-cAMPS, Na, PKA Inhibitor VI
      DescriptionCell-permeable, potent, reversible, and metabolically stable antagonist of cAMP that is resistant to the action of mammalian cyclic nucleotide phosphodiesterases. Rp-8-Br-cAMPS is more lipophilic as compared to 8-Br-cAMP and Rp-cAMPS. In contrast to other common ATP-site inhibitors or to its parent compound Rp-cAMPS, Rp-8-Br-cAMPS discriminates between both isozymes of protein kinase A, preferring type I, thus providing additional selectivity. By occupying cAMP binding sites, prevents dissociation and activation of the kinase holoenzyme. λ = 264 nm (H2O, pH 7.0); εmax 17,000 M-1cm-1.
      FormLyophilized
      Chemical formulaC₁₀H₁₀BrN₅O₅PS · Na
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityH₂O (40 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesCalaghan, S.C., et al. 1999. Pflugers Arch. 437, 780.
      Gjertsen, B.T., et al. 1995. J. Biol. Chem. 270, 20599.
      Yokozaki, H., et al. 1992. Cancer Res. 52, 2504.
      Dostmann, W.R. et al. 1990. J. Biol. Chem. 265, 10484.
      Citation
    • Ralf Gutzmer, et al. (2005) Histamine H4 receptor stimulation suppresses IL-12p70 production and mediates chemotaxis in human monocyte-derived dendritic cells. Journal of Immunology 5224-5232.
      		•