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114700 Activin A, Human, Recombinant, CHO Cells

Activin A, Human, Recombinant, is a member of the TGF-β superfamily that is involved in the negative regulation of B lineage lymphocytes. A disulfide-linked homodimer of two 116-a.a. βA subunits.

Activin A, Human, Recombinant, CHO Cells MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
114700
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Overview

Key Spec Table

Purity
≥95% by SDS-PAGE

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114700-10UG
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      Description
      OverviewRecombinant, human activin A (disulfide-linked homodimer of two 116-amino acid residue βA subunits) expressed in CHO cells. Mature βA-monomer lacks a potential N-linked glycosylation site and has a calculated molecular weight of 13 kDa. A member of the TGF-β superfamily that is involved in the negative regulation of B lineage lymphocytes. Shown to play an important role in the regulation of hormonogenesis, cellular homeostasis, and differentiation programs. Reported to inhibit endogenous production of IL-6.
      Catalogue Number114700
      Brand Family Calbiochem®
      References
      ReferencesZipori, D., et al. 2001. J. Leukoc. Biol. 69, 867.
      Hedger, M.P., et al. 2000. Cytokine 12, 595.
      Woodruff, T.K. 1998. Biochem. Pharmacol. 55, 953.
      Ying, S.Y., et al. 1997. Proc. Soc. Exp. Biol. Med. 214, 114.
      Schwall, R.H., and Lei, C. 1991. Methods Enzymol. 198, 340.
      Mason, A., et al. 1986. Biochem. Biophys. Res. Commun. 135, 957.
      Product Information
      FormLyophilized
      FormulationLyophilized from sterile filtered 35% acetonitrile, 0.1% TFA, 50 µg BSA/µg Activin A.
      Quality LevelMQ100
      Biological Information
      Biological activityED₅₀ = 0.5-2.0 ng/ml as measured by its ability to induce hemoglobin expression in K562 cells
      Purity≥95% by SDS-PAGE
      Physicochemical Information
      ContaminantsEndotoxin: ≤100 pg/µg Activin A
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C. Avoid freeze/thaw cycles of solutions.
      Global Trade Item Number
      Catalogue Number GTIN
      114700-10UG 04055977208085