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504844 7-Chlorokynurenic Acid Sodium Salt - CAS 1263094-00-3 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 7-Chloro-4-hydroxyquinoline-2-carbo-xylic acid sodium salt

Primary Target: NMDA receptors
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504844
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1263094-00-3C₁₀H₅ClNNaO₃

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      		 Glass bottle 10 mg
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      Description
      OverviewA very potent, water-soluble antagonist of the NMDA receptors complex acting at the strychnine-insensitive glycine binding site (IC50 = 0.56 µM). Also a potent inhibitor of glutamate transporter. Often used in studies of neuroprotection and schizophrenia.
      Catalogue Number504844
      Brand Family Calbiochem®
      Synonyms7-Chloro-4-hydroxyquinoline-2-carbo-xylic acid sodium salt
      References
      ReferencesKemp, J., et al. 1988. Proc. Natl. Acad. Sci. U.S.A. 85, 6550.
      Kretschmer, D., et al. 1995. Eur. J. Pharmacol. 280, 37.
      Bartlett, D., et al. 1999. Neuropharmacol. 37, 839.
      Moroni, F., et al. 1991. Eur. J. Pharmacol. 199, 32.
      Stone, W., et al. 2012. FEBS J. 279, 1386.
      Vécsei, L., et al. 2012. Nat. Rev. Drug Disc. 12, 64.
      Product Information
      CAS number1263094-00-3
      FormWhite solid
      Hill FormulaC₁₀H₅ClNNaO₃
      Chemical formulaC₁₀H₅ClNNaO₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNMDA receptors
      Primary Target IC<sub>50</sub>0.56 →M
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      5.04844.0001 04055977243611

      Documentation

      7-Chlorokynurenic Acid Sodium Salt - CAS 1263094-00-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Kemp, J., et al. 1988. Proc. Natl. Acad. Sci. U.S.A. 85, 6550.
      Kretschmer, D., et al. 1995. Eur. J. Pharmacol. 280, 37.
      Bartlett, D., et al. 1999. Neuropharmacol. 37, 839.
      Moroni, F., et al. 1991. Eur. J. Pharmacol. 199, 32.
      Stone, W., et al. 2012. FEBS J. 279, 1386.
      Vécsei, L., et al. 2012. Nat. Rev. Drug Disc. 12, 64.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-July-2013 JSW
      Synonyms7-Chloro-4-hydroxyquinoline-2-carbo-xylic acid sodium salt
      DescriptionA very potent, water-soluble antagonist of the NMDA receptors complex acting at the strychnine-insensitive glycine binding site (IC50 = 0.56 µM). Also a potent inhibitor of glutamate transporter. Often used in studies of neuroprotection and schizophrenia.
      FormWhite solid
      CAS number1263094-00-3
      Chemical formulaC₁₀H₅ClNNaO₃
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityH₂O (100 mM)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesKemp, J., et al. 1988. Proc. Natl. Acad. Sci. U.S.A. 85, 6550.
      Kretschmer, D., et al. 1995. Eur. J. Pharmacol. 280, 37.
      Bartlett, D., et al. 1999. Neuropharmacol. 37, 839.
      Moroni, F., et al. 1991. Eur. J. Pharmacol. 199, 32.
      Stone, W., et al. 2012. FEBS J. 279, 1386.
      Vécsei, L., et al. 2012. Nat. Rev. Drug Disc. 12, 64.