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164603
Sigma-Aldrich3-Nitropropionic acid - CAS 504-88-1 - Calbiochem
A cell-permeable, irreversible inactivator (~3 mM) of succinate dehydrogenase that upon oxidation by Complex II forms a covalent adduct with Arg297 in the active site of the enzyme.
More>>A cell-permeable, irreversible inactivator (~3 mM) of succinate dehydrogenase that upon oxidation by Complex II forms a covalent adduct with Arg297 in the active site of the enzyme. Less<<
MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Description
Overview
A cell-permeable, irreversible inactivator (~3 mM) of succinate dehydrogenase that upon oxidation by Complex II forms a covalent adduct with Arg297 in the active site of the enzyme. Disrupts the blood-brain barrier and causes severe energy (ATP) impairment. Also replicates several pathophysiological symptoms of Huntington disease, including spontaneous choreiform and dystonic movements and degeneration of striatum in rodent models. Chronic administration of 3-NP (38 mg/kg/day) is shown to cause activation of c-Jun kinase in striatum.
Catalogue Number
164603
Brand Family
Calbiochem®
Synonyms
3-Nitropropionic acid, 3-NP, 3-NPA, 3NPA
References
References
Beal, M., et al. 1993, J. Neurosci.13, 4181. Pang, Z., et al. 1997, J. Neuroscience17, 3064. Huang, L., et al. 2006, J. Bio. Chem. 281, 5965. Garcia, M., et al. 2002, J. Neurosci. 22, 2174. Kim, G. W., et al. 2003, J. Neurosci.23, 8733.
Toxic if swallowed. Irritating to eyes, respiratory system and skin.
S Phrase
S: 26-36-45
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code
Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity
Toxic
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
+2°C to +8°C
Protect from Light
Protect from light
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas
Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number
GTIN
164603-50MG
04055977207590
Documentation
3-Nitropropionic acid - CAS 504-88-1 - Calbiochem SDS
3-Nitropropionic acid - CAS 504-88-1 - Calbiochem Certificates of Analysis
Title
Lot Number
164603
References
Reference overview
Beal, M., et al. 1993, J. Neurosci.13, 4181. Pang, Z., et al. 1997, J. Neuroscience17, 3064. Huang, L., et al. 2006, J. Bio. Chem. 281, 5965. Garcia, M., et al. 2002, J. Neurosci. 22, 2174. Kim, G. W., et al. 2003, J. Neurosci.23, 8733.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
27-February-2024 JSW
Synonyms
3-Nitropropionic acid, 3-NP, 3-NPA, 3NPA
Description
A cell-permeable, irreversible inactivator (~3 mM) of succinate dehydrogenase that upon oxidation by Complex II forms a covalent adduct with Arg297 in the active site of the enzyme. Disrupts the blood-brain barrier and causes severe energy (ATP) impairment. Also replicates several pathophysiological symptoms of Huntington disease, including spontaneous choreiform and dystonic movements and degeneration of striatum in rodent models. Chronic administration of 3-NP (38 mg/kg/day) is shown to cause activation of c-Jun kinase in striatum.
Form
Light yellow powder
Intert gas (Yes/No)
Packaged under inert gas
CAS number
504-88-1
Chemical formula
C₃H₅NO₄
Structure formula
Purity
≥97% by HPLC
Solubility
DMSO or Ethanol (100 mg/ml)
Storage
Protect from light +2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Toxic
References
Beal, M., et al. 1993, J. Neurosci.13, 4181. Pang, Z., et al. 1997, J. Neuroscience17, 3064. Huang, L., et al. 2006, J. Bio. Chem. 281, 5965. Garcia, M., et al. 2002, J. Neurosci. 22, 2174. Kim, G. W., et al. 2003, J. Neurosci.23, 8733.
