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565762 γ-Secretase Inhibitor V

565762
  
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      Overview

      Key Spec Table

      Empirical Formula
      C₂₃H₂₈N₂O₄
      Description
      Overview

      This product has been discontinued.





      A cell-permeable, reversible inhibitor of γ-secretase that is reported to inhibit the release of Aβx-40 (ED50 = 5 µM) in HEK293 cells stably transfected with the Amyloid Precursor Protein Swedish mutants.
      Catalogue Number565762
      Brand Family Calbiochem®
      SynonymsZ-LF-CHO, N-Benzyloxycarbonyl-Leu-phenylalaninal
      References
      ReferencesSinha, S. and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.
      Product Information
      FormWhite lyophilized solid
      Hill FormulaC₂₃H₂₈N₂O₄
      Chemical formulaC₂₃H₂₈N₂O₄
      ReversibleY
      Structure formula ImageStructure formula Image
      Biological Information
      Primary Targetx-40 in HEK293 cells stably transfected with the Amyloid Precursor Protein Swedish mutants
      Primary Target IC<sub>50</sub>ED₅₀ = 5 µM
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceZ-Leu-Phe-CHO
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      565762 0