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565762 γ-Secretase Inhibitor V

γ-Secretase Inhibitor V MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Z-LF-CHO, N-Benzyloxycarbonyl-Leu-phenylalaninal

Primary Target: Aβx-40 in HEK293 cells stably transfected with the Amyloid Precursor Protein Swedish mutants
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₂₃H₂₈N₂O₄
      Description
      Overview

      This product has been discontinued.





      A cell-permeable, reversible inhibitor of γ-secretase that is reported to inhibit the release of Aβx-40 (ED50 = 5 µM) in HEK293 cells stably transfected with the Amyloid Precursor Protein Swedish mutants.
      Catalogue Number565762
      Brand Family Calbiochem®
      SynonymsZ-LF-CHO, N-Benzyloxycarbonyl-Leu-phenylalaninal
      References
      ReferencesSinha, S. and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.
      Product Information
      FormWhite lyophilized solid
      Hill FormulaC₂₃H₂₈N₂O₄
      Chemical formulaC₂₃H₂₈N₂O₄
      ReversibleY
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetAβx-40 in HEK293 cells stably transfected with the Amyloid Precursor Protein Swedish mutants
      Primary Target IC<sub>50</sub>ED₅₀ = 5 µM
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceZ-Leu-Phe-CHO
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      565762 0

      Documentation

      γ-Secretase Inhibitor V Certificates of Analysis

      TitleLot Number
      565762

      References

      Reference overview
      Sinha, S. and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-September-2008 RFH
      SynonymsZ-LF-CHO, N-Benzyloxycarbonyl-Leu-phenylalaninal
      DescriptionA cell-permeable, reversible inhibitor of g-secretase that inhibits the release of Aβx-40 (ED50 = 5.0 µM) from HEK293 cells stably transfected with Amyloid Precursor Protein Swedish mutants.
      FormWhite lyophilized solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₃H₂₈N₂O₄
      Peptide SequenceZ-Leu-Phe-CHO
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Toxicity Standard Handling
      ReferencesSinha, S. and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.